RANBP3 Antibody

RAN Binding Protein 3 (RANBP3) is a protein encoded by the RANBP3 gene in humans. This protein is involved in various cellular processes, including nuclear export, protein transport, and intracellular transport. It is found in both the nucleus and cytoplasm and plays a crucial role in the regulation of the cell cycle and mitotic centrosome separation .

RANBP3 contains a RanBD1 domain, which is essential for its interaction with other proteins involved in nuclear transport. This protein is part of a heteromeric complex that facilitates the export of proteins and RNA from the nucleus to the cytoplasm. It has been shown to interact with RCC1 and XPO1, which are key players in the nuclear export pathway .

RANBP3 has been implicated in various diseases, including renal cell carcinoma (RCC). High expression of RANBP3 is linked to a favorable prognostic outcome in RCC. Loss of RANBP3 expression can lead to the transformation of renal epithelial cells towards a renal clear cell carcinoma-like phenotype, characterized by increased cell migration and colony-forming capacity . Additionally, RANBP3 has been reported as a potential regulator in melanoma, hepatocellular carcinoma, prostate cancer, and ovarian cancer .

The mouse anti-human RANBP3 antibody is used in research to study the expression and function of RANBP3 in various cellular contexts. This antibody can be used in techniques such as immunofluorescence, Western blotting, and immunoprecipitation to detect RANBP3 in human cells. It is a valuable tool for investigating the role of RANBP3 in cellular processes and disease mechanisms.