PTGR2 Human

Prostaglandin Reductase 2 (PTGR2), also known as 15-oxoprostaglandin 13-reductase, is an enzyme that plays a crucial role in the metabolism of prostaglandins. Prostaglandins are bioactive lipids that act as signaling molecules involved in various physiological processes, including inflammation, pain perception, and the regulation of blood pressure .

PTGR2 is a zinc-binding alcohol dehydrogenase domain-containing protein. The recombinant form of PTGR2 is typically expressed in Escherichia coli and purified to a high degree of purity, often exceeding 90% . The recombinant protein is used in various biochemical assays to study its function and interactions.

PTGR2 functions as a 15-oxo-prostaglandin 13-reductase, acting on substrates such as 15-keto-PGE1, 15-keto-PGE2, and their alpha forms, with the highest activity towards 15-keto-PGE2 . This enzyme is involved in the reduction of the keto group at the 15th position of prostaglandins, which is a critical step in the inactivation and clearance of these signaling molecules.

The activity of PTGR2 is essential for the regulation of prostaglandin levels in the body. Dysregulation of prostaglandin metabolism can lead to various pathological conditions, including chronic inflammation, pain, and cardiovascular diseases . By modulating the levels of active prostaglandins, PTGR2 helps maintain homeostasis and prevent excessive inflammatory responses.

Recombinant PTGR2 is widely used in research to understand its role in prostaglandin metabolism and its potential as a therapeutic target. Studies have shown that overexpression of PTGR2 can repress the transcriptional activity of peroxisome proliferator-activated receptor gamma (PPARG) and inhibit adipocyte differentiation . This suggests that PTGR2 may have broader implications in metabolic regulation and disease.