PTGES2 Human
Description
PTGES2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Prostaglandin E synthase 2 (PTGES2) is an enzyme found on the membrane of cells. It plays a crucial role in producing prostaglandin E2 (PGE2) by converting prostaglandin H2. Besides its role in PGE2 synthesis, PTGES2 can activate transcription regulated by a gamma-INF-activated transcription element. PTGES2 is found in various tissues throughout the body. In the heart, it is present in areas like the apex, inter-ventricular septum, atria, and ventricles, but not in the aorta. PTGES2 is also present in the developing heart. Within the brain, it is located in regions such as the cerebellum, occipital lobe, frontal lobe, and parietal lobe. Other sites of PTGES2 expression include lymph nodes, skeletal muscle, kidney, and trachea. Notably, it is absent in the thymus and lung. PTGES2 is found at elevated levels in colorectal cancer.
Product Science Overview
PTGES2 is a membrane-associated protein, primarily localized in the Golgi apparatus. It has an N-terminal domain that anchors it in the Golgi membrane, while its catalytic domain resides in the cytoplasm . Proteolysis within the cell can generate a truncated soluble form that resides in the cytosol .
The primary function of PTGES2 is to catalyze the conversion of PGH2 to PGE2, a process that is crucial for various physiological functions, including inflammation, fever, and pain regulation . PGE2 is a potent lipid mediator involved in numerous biological processes such as immune responses, gastrointestinal integrity, and reproductive functions .
PTGES2 is constitutively expressed in various tissues, with the highest expression observed in the brain, heart, skeletal muscle, kidney, and liver . It is also found in select cell types, including striated muscle cells, neurons, hepatocytes, and astrocytes . The enzyme’s activity is regulated by various factors, including cytokines and growth factors, which can modulate its expression and function .
Alterations in PTGES2 expression and function have been associated with several diseases. For instance, dysregulation of PGE2 synthesis is implicated in inflammatory conditions, cardiovascular diseases, and certain cancers . Understanding the role of PTGES2 in these diseases can provide insights into potential therapeutic targets for drug development.
