PSG5 Human, Sf9
Pregnancy Specific Beta-1-Glycoprotein 5, Pregnancy-Specific Beta-1 Glycoprotein, Fetal Liver Non-Specific Cross-Reactive Antigen 3, Pregnancy-Specific Beta-1-Glycoprotein 5, FL-NCA-3, PS-beta-G-5, PSBG-5, PSG.
Greater than 90.0% as determined by SDS-PAGE.
Description
PSG5 Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 310 amino acids (35-335 a.a.) and having a molecular mass of 35.1kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). PSG5 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
Pregnancy Specific Beta-1-Glycoprotein 5, Pregnancy-Specific Beta-1 Glycoprotein, Fetal Liver Non-Specific Cross-Reactive Antigen 3, Pregnancy-Specific Beta-1-Glycoprotein 5, FL-NCA-3, PS-beta-G-5, PSBG-5, PSG.
ADLQVTIEAL PPKVSEGKDV LLLVHNLPQN LAGYIWYKGQ LMDLYHYITS YVVDGQINIY GPAYTGRETV YSNASLLIQN VTREDAGSYT LHIIKRGDRT RGVTGYFTFN LYLKLPKPYI TINNSKPREN KDVLAFTCEP KSENYTYIWW LNGQSLPVSP RVKRPIENRI LILPSVTRNE
TGPYECEIRD RDGGMRSDPV TLNVLYGPDL PSIYPSFTYY RSGENLYLSC FAESNPPAEY FWTINGKFQQ SGQKLSIPQI TTKHRGLYTC SVRNSATGKE SSKSMTVEVS APSGIGRLPL LNPIHHHHHH
Product Science Overview
Pregnancy Specific Beta-1-Glycoprotein 5 (PSG5) is a member of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. This glycoprotein is primarily produced by the placental syncytiotrophoblasts during pregnancy and plays a crucial role in fetal development and maternal immune modulation.
The PSG5 gene is a protein-coding gene that is part of a larger family of pregnancy-specific glycoproteins (PSGs). These glycoproteins are encoded by a cluster of genes located on chromosome 19 in humans . The PSG5 protein consists of a single, glycosylated polypeptide chain containing 310 amino acids, with a molecular mass of approximately 35.1 kDa .
PSG5 is exclusively expressed in fetal syncytiotrophoblast cells and is one of the most abundant fetal proteins found in maternal blood during pregnancy . The primary function of PSG5 and other PSGs is to modulate the maternal immune system, potentially preventing the rejection of the semi-allogeneic fetus. Additionally, PSGs may facilitate the access of trophoblast cells to maternal resources via the blood system .
The PSG gene family has evolved rapidly, particularly in primates with hemochorial placentation, where there is intimate contact between fetal and maternal blood systems . This rapid evolution suggests that PSGs are still adapting to optimize fetal-maternal interactions and possibly serve as soluble pathogen decoy receptors .
Human recombinant PSG5 produced in Sf9 insect cells is a biotechnologically engineered form of the protein. This recombinant protein is used in various research and clinical applications to study its function and potential therapeutic uses. The recombinant PSG5 maintains the same structural and functional properties as the naturally occurring protein, making it a valuable tool for scientific investigations .
