PSG1 Human
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Description
PSG1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Pregnancy-Specific Beta-1-Glycoprotein 1 (PSG1) is part of a group of transcription factors that become phosphorylated when they attach to promoter sequences. PSGs are classified as carcinoembryonic antigen (CEA) family members and act as early indicators of syncytiotrophoblast formation. It is believed that PSG1 plays a role in placental vascular development by increasing VEGF-A production and encouraging the creation of endothelial tubes. As a significant product of the syncytiotrophoblast, PSG1 can reach levels of 100-290 mg/l in the serum of pregnant women by the end of pregnancy.
Recombinant human PSG1, produced in E. coli, is a single polypeptide chain that lacks glycosylation. It comprises 408 amino acids (positions 35-419) and has a molecular weight of 45.9 kDa. The PSG1 protein has a 23 amino acid His-tag attached to its N-terminus and is purified using specialized chromatographic methods.
For best results within 2-4 weeks, store the vial at 4°C. For longer storage, freeze at -20°C. Consider adding a carrier protein (0.1% HSA or BSA) for extended storage. Avoid repeatedly freezing and thawing the product.
Product Science Overview
PSG1 is a highly glycosylated protein, consisting of a core protein covalently bound to carbohydrates. It contains four immunoglobulin domains, which contribute to its stability and function . PSG1 is secreted by trophoblast cells of the human placenta and becomes one of the most abundant proteins in maternal serum during the later stages of pregnancy .
The primary function of PSG1 is to act as an immunomodulator, protecting the growing fetus by modulating the maternal immune response . It has been shown to induce the production of transforming growth factor beta 1 (TGFB1) and vascular endothelial growth factor A (VEGFA), which play crucial roles in placental vascular morphogenesis and immune tolerance .
PSG1 levels in maternal serum can serve as a biomarker for pregnancy health. Abnormal levels of PSG1 have been associated with complicated pregnancies, highlighting its importance in maintaining a successful pregnancy . Additionally, PSG1’s role in inducing proangiogenic growth factors suggests its potential therapeutic applications in conditions requiring enhanced vascularization .
Human recombinant PSG1 is produced using recombinant DNA technology, allowing for the study and potential therapeutic use of this protein. Recombinant PSG1 retains the structural and functional properties of the naturally occurring protein, making it a valuable tool for research and clinical applications.
