PRDX6 Antibody
Description
Product Specs
The antibody solution is supplied at a concentration of 1mg/ml and is prepared in a buffer consisting of PBS at pH 7.4, 10% glycerol, and 0.02% sodium azide.
Product Science Overview
Peroxiredoxin-6 (PRDX6) is a member of the peroxiredoxin family of antioxidant enzymes, which play a crucial role in reducing oxidative stress within cells. PRDX6 is unique among peroxiredoxins as it contains only one conserved cysteine residue, classifying it as a 1-Cys peroxiredoxin . This enzyme is involved in the reduction of hydrogen peroxide and organic hydroperoxides, thereby protecting cells from oxidative damage .
PRDX6 is multifunctional, exhibiting both glutathione peroxidase and phospholipase A2 activities . It is widely expressed in various tissues, including the liver, lungs, and red blood cells . The enzyme’s ability to reduce phospholipid hydroperoxides is particularly important in maintaining the integrity of cellular membranes .
PRDX6 plays a significant role in cellular defense mechanisms against oxidative stress. It is involved in various physiological processes, including:
- Cell proliferation and differentiation: PRDX6 is implicated in the regulation of cell growth and differentiation .
- Apoptosis: The enzyme helps in preventing programmed cell death by reducing oxidative stress .
- Lipid metabolism: PRDX6’s phospholipase A2 activity is crucial for lipid remodeling and repair of cell membranes .
Mouse anti-human PRDX6 antibodies are monoclonal antibodies developed to specifically target and bind to human PRDX6. These antibodies are commonly used in various research applications, including:
The use of mouse anti-human PRDX6 antibodies has facilitated numerous studies aimed at understanding the role of PRDX6 in health and disease. For instance:
- Lung Injury Studies: Research has shown that PRDX6 protects pulmonary epithelial cells from oxidative damage caused by cigarette smoke .
- Inflammation and Oxidative Stress: Inactivation of PRDX6’s phospholipase A2 activity has been associated with reduced lung inflammation and oxidative stress in mouse models .
