PITPNB Human

Phosphatidylinositol Transfer Protein Beta Human Recombinant
Cat. No.
BT3958
Source
Escherichia Coli.
Synonyms
Phosphatidylinositol transfer protein beta isoform, PI-TP-beta, PtdIns transfer protein beta, PtdInsTP beta, PITPNB, VIB1B, PtdInsTP.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

PITPNB Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 291 amino acids (1-271 a.a.) and having a molecular mass of 33.7kDa. The PITPNB is purified by proprietary chromatographic techniques.

Product Specs

Introduction
Phosphatidylinositol transfer protein beta isoform (PITPNB) is located in the cytoplasm and facilitates the movement of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes. It plays a crucial role in PI mobilization from the endoplasmic reticulum and regulates its release from Golgi network vesicles. PITPNB is widely present in various tissues.
Description
Recombinant human PITPNB, expressed in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 291 amino acids, including a 20 amino acid His tag at the N-terminus (1-271 a.a.), and has a molecular weight of 33.7kDa. The protein is purified using proprietary chromatographic techniques.
Physical Appearance
Clear, sterile solution.
Formulation
The PITPNB solution is provided at a concentration of 1 mg/ml in a buffer containing 20mM Tris-HCl (pH 8.0), 1mM DTT, and 10% glycerol.
Stability
For short-term storage (2-4 weeks), keep at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Repeated freezing and thawing should be avoided.
Purity
The purity is greater than 95.0% as determined by SDS-PAGE analysis.
Synonyms
Phosphatidylinositol transfer protein beta isoform, PI-TP-beta, PtdIns transfer protein beta, PtdInsTP beta, PITPNB, VIB1B, PtdInsTP.
Source
Escherichia Coli.
Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MVLIKEFRVV LPCSVQEYQV GQLYSVAEAS KNETGGGEGI EVLKNEPYEK DGEKGQYTHK IYHLKSKVPA FVRMIAPEGS LVFHEKAWNA YPYCRTIVTN EYMKDDFFIK IETWHKPDLG TLENVHGLDP NTWKTVEIVH IDIADRSQVE PADYKADEDP ALFQSVKTKR GPLGPNWKKE LANSPDCPQM CAYKLVTIKF KWWGLQSKVE NFIQKQEKRI FTNFHRQLFC WIDKWIDLTM EDIRRMEDET QKELETMRKR GSVRGTSAAD V.

Product Science Overview

Structure and Function

PITPNB is involved in the COPI complex-mediated retrograde transport from the Golgi apparatus to the endoplasmic reticulum (ER). This transport is essential for maintaining the proper function and structure of the Golgi and ER . The protein catalyzes the transfer of PI and PC, which are vital components of cell membranes .

Gene and Protein Information

The PITPNB gene is located on chromosome 22 and is a protein-coding gene. It has several aliases, including PI-TP-Beta and PtdInsTP Beta . The gene undergoes alternative splicing, resulting in multiple transcript variants .

Biological Pathways

PITPNB is associated with several biological pathways, including:

  • Glycerophospholipid biosynthesis
  • Metabolism

These pathways are crucial for the synthesis and regulation of lipids within the cell .

Clinical Significance

Mutations or dysregulation of the PITPNB gene have been linked to various diseases, such as:

  • Retinopathy, Pericentral Pigmentary, Autosomal Recessive
  • Developmental and Epileptic Encephalopathy 93

These conditions highlight the importance of PITPNB in normal cellular function and development .

Research and Applications

Human recombinant PITPNB is used in research to study its role in lipid transfer and its involvement in various cellular processes. Understanding the function of PITPNB can provide insights into the mechanisms of diseases associated with lipid metabolism and transport.

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PITPNA Human
Phosphatidylinositol Transfer Protein Alpha Human Recombinant
Cat. No.
BT3842
Source
Escherichia Coli.
THE BIOTEK
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