PITPNA Human
Description
PITPNA Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 290 amino acids (1-270 a.a.) and having a molecular mass of 33.9kDa. The PITPNA is purified by proprietary chromatographic techniques.
Product Specs
MGSSHHHHHH SSGLVPRGSH MVLLKEYRVI LPVSVDEYQV GQLYSVAEAS KNETGGGEGV EVLVNEPYEK DGEKGQYTHK IYHLQSKVPT FVRMLAPEGA LNIHEKAWNA YPYCRTVITN EYMKEDFLIK IETWHKPDLG TQENVHKLEP EAWKHVEAVY IDIADRSQVL SKDYKAEEDP AKFKSIKTGR GPLGPNWKQE LVNQKDCPYM CAYKLVTVKF KWWGLQNKVE NFIHKQERRL FTNFHRQLFC WLDKWVDLTM DDIRRMEEET KRQLDEMRQK DPVKGMTADD.
Product Science Overview
Phosphatidylinositol Transfer Protein Alpha (PITPNA) is a member of a family of lipid-binding proteins that play a crucial role in the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membrane surfaces. This protein is essential for various cellular processes, including phospholipase C signaling and the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by phosphoinositide-3-kinase .
The PITPNA gene is located on chromosome 17 in humans and encodes a protein that is involved in lipid metabolism and transport. The protein has a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions . The gene is also associated with several diseases, including Brunner Syndrome and Retinal Degeneration .
PITPNA catalyzes the transfer of PI and PC between membranes, which is vital for maintaining the proper distribution of these lipids within the cell. This transfer is crucial for various signaling pathways, including interleukin-12 family signaling and nervous system development . The protein’s ability to bind and transport lipids is essential for its role in cellular processes such as visual perception, lipid metabolism, and axonogenesis .
Phosphatidylinositol transfer proteins are a diverse set of cytosolic phospholipid transfer proteins that are distinguished by their ability to transfer phospholipids between membranes in vitro . The human recombinant form of PITPNA is used in research to study its role in cellular processes and its potential implications in various diseases.
The study of PITPNA has significant implications for understanding lipid metabolism and its role in various diseases. Researchers use the human recombinant form of this protein to investigate its function and potential therapeutic applications. The protein’s involvement in critical signaling pathways makes it a valuable target for research in fields such as neurobiology and immunology .
