PI3 Human

The PI3 gene is located on chromosome 20q12-q13 and is part of a cluster of WFDC domain family genes . The protein encoded by this gene contains a single WAP domain and is known for its elastase-specific inhibitory activity . This means that PI3 can inhibit the activity of elastase, an enzyme that breaks down elastin and other proteins in the extracellular matrix .

PI3 functions primarily as an antimicrobial peptide and an elastase-specific inhibitor . It plays a crucial role in the body’s defense mechanisms by inhibiting the activity of neutrophil and pancreatic elastase, thereby preventing elastase-mediated tissue proteolysis . Additionally, PI3 has been shown to inhibit certain nicotinic acetylcholine receptors and transient receptor potential cation channels .

The expression of PI3 is upregulated in response to bacterial lipopolysaccharides and cytokines, indicating its role in the innate immune response . PI3 is associated with several diseases, including pustular psoriasis and impetigo . Its antimicrobial properties make it a potential therapeutic target for treating infections caused by Gram-positive and Gram-negative bacteria, as well as fungal pathogens .

Recombinant PI3 (Human) is produced using recombinant DNA technology, which involves inserting the human PI3 gene into a suitable expression system to produce the protein in large quantities. This recombinant form retains the same structure and function as the naturally occurring protein and is used in various research and therapeutic applications .

Recombinant PI3 is utilized in research to study its role in immune response and disease mechanisms. It is also being explored for its potential therapeutic applications in treating inflammatory diseases and bacterial infections .