PARK7 Antibody
Description
Product Specs
Product Science Overview
Parkinson Disease Protein 7 (PARK7), also known as DJ-1, is a multifunctional protein that plays a crucial role in protecting cells against oxidative stress and cell death. It is involved in various cellular processes, including neuroprotection, male fertility, and cell growth. Mutations in the DJ-1 gene have been associated with rare forms of autosomal recessive early-onset Parkinson’s disease .
PARK7 is a protein consisting of 189 amino acids. It acts as an oxidative stress sensor and redox-sensitive chaperone and protease. The protein is involved in neuroprotective mechanisms, such as stabilizing NFE2L2 and PINK1 proteins, and modulating the NF-kappa-B signaling pathway . PARK7 also functions as a protein and nucleotide deglycase, repairing glycated proteins and nucleotides, and preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage .
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the progressive degeneration of dopaminergic neurons in the nigrostriatal pathway. The accumulation of certain α-synuclein species is a hallmark of the disease . While monogenic causes of PD account for a minority of cases, the investigation of genetic alterations, such as mutations in the DJ-1 gene, provides insights into individual disease mechanisms and opportunities for drug development .
The mouse anti-human PARK7 monoclonal antibody is derived from the hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PARK7 amino acids 1-189 purified from E. coli . This antibody is used in research to study the role of PARK7 in various cellular processes and its involvement in Parkinson’s disease.
The mouse anti-human PARK7 antibody is a valuable tool in research for studying the molecular mechanisms of Parkinson’s disease. It helps in understanding the role of PARK7 in oxidative stress response, cell death, and neuroprotection. Additionally, it aids in the investigation of potential therapeutic targets for the treatment of Parkinson’s disease and other neurodegenerative disorders .
