ORM2 Human

ORM2 is a glycoprotein with a molecular weight of approximately 24.3 kDa . The recombinant form of ORM2 is often expressed in Escherichia coli (E. coli) and includes an N-terminal His-tag for purification purposes . The amino acid sequence of human recombinant ORM2 typically spans residues 19-201 of the native protein .

The specific function of ORM2 is not fully understood, but it is believed to play a role in immunosuppression . ORM2 has been shown to modulate immune responses and may be involved in the regulation of inflammation . Recent studies have indicated that ORM2 can directly promote the production of pro-inflammatory mediators such as IL-6, TNF-α, and CXCL8 (IL-8) via the NF-κB and p38 MAPK pathways .

ORM2 is of particular interest in the context of chronic inflammatory diseases. For example, elevated levels of ORM2 have been observed in patients with rheumatoid arthritis (RA), and it has been implicated in the pathogenesis of the disease . ORM2 expression is upregulated in the synovial fluids and membranes of RA patients, and it has been shown to exacerbate the severity of arthritis in animal models .

Recombinant human ORM2 is used extensively in research to study its role in inflammation and immune regulation. It is also utilized in the development of diagnostic markers for chronic inflammatory diseases . The recombinant protein is typically stored at -20°C to maintain its stability and activity .