ODC1 Human

The ODC1 gene is located on chromosome 2p25.1 and encodes a protein that consists of 461 amino acids . The enzyme forms a homodimer, which is necessary for its catalytic activity . The gene has a high turnover rate, meaning it is rapidly synthesized and degraded in response to growth-promoting stimuli .

ODC1 is the rate-limiting enzyme in the polyamine biosynthesis pathway . This pathway is critical for cell growth and differentiation. The enzyme’s activity is tightly regulated, and its expression levels can vary significantly in response to various stimuli, including hormones, growth factors, and oncogenes .

Mutations or dysregulation of the ODC1 gene have been associated with several diseases, including colorectal cancer and Bachmann-Bupp Syndrome . The enzyme’s role in cell proliferation makes it a target for cancer research, as inhibiting its activity could potentially slow down the growth of cancer cells .

Human recombinant ODC1 is produced using recombinant DNA technology, which involves inserting the human ODC1 gene into bacterial or yeast cells to produce the enzyme in large quantities . This recombinant enzyme is used in various research applications, including studying the polyamine biosynthesis pathway and developing potential therapeutic interventions .

ODC1 is a subject of extensive research due to its critical role in cell growth and proliferation. Researchers are exploring ways to modulate its activity to develop treatments for cancer and other diseases associated with abnormal cell growth . Additionally, the enzyme is used in biochemical assays to study the effects of various compounds on the polyamine biosynthesis pathway .