NDRG1 Human
Description
The NDRG1 is purified by proprietary chromatographic techniques.
Product Specs
VCHVDAPGQQ DGAASFPAGY MYPSMDQLAE MLPGVLQQFG LKSIIGMGTG AGAYILTRFA LNNPEMVEGL VLINVNPCAE GWMDWAASKI SGWTQALPDM VVSHLFGKEE MQSNVEVVHT YRQHIVNDMN PGNLHLFINA YNSRRDLEIE RPMPGTHTVT LQCPALLVVG DSSPAVDAVV ECNSKLDPTK TTLLKMADCG GLPQISQPAK LAEAFKYFVQ GMGYMPSASM TRLMRSRTAS GSSVTSLDGT RSRSHTSEGT RSRSHTSEGT RSRSHTSEGA HLDITPNSGA AGNSAGPKSM EVSCLEHHHH HH
Product Science Overview
NDRG1 is an intracellular protein that plays a crucial role in various physiological processes, including cellular differentiation, cell cycle regulation, and response to cellular stress . It is expressed in a wide range of tissues, particularly in epithelial tissues, and is found in both the cytoplasm and nucleus of cells .
NDRG1 has been extensively studied for its role in cancer. It is well-characterized as a metastasis suppressor in several types of cancer, including colon, prostate, and breast cancers . The protein is known to inhibit tumor progression by suppressing metastasis, primary tumor growth, and angiogenesis . Interestingly, NDRG1 expression is often downregulated in neoplastic tissues compared to normal tissues .
Recent studies have shown that NDRG1 expression is associated with aggressive features of breast cancer, such as metastasis to the axillary lymph nodes and human epidermal growth factor receptor 2 (Her2) status . Increased NDRG1 expression has been linked to both less aggressive and more aggressive behavior depending on the breast cancer subtype .
NDRG1 has emerged as a potential therapeutic target for cancer treatment. Novel iron chelators with selective antitumor activity, such as Dp44mT and DpC, have been shown to upregulate NDRG1 in cancer cells . These chelators exhibit antimetastatic potential only in cells expressing NDRG1, highlighting the importance of this protein in cancer chemotherapy .
