NDRG1 Antibody

NDRG1, a cytoplasmic protein, plays a crucial role in various cellular processes such as stress and hormone responses, cell growth, and differentiation. As a member of the NDRG α/β-hydrolase family, it is recognized as a tumor suppressor and heavy metal-response protein. Its functions encompass cell-cycle regulation, cellular differentiation, apoptosis, hypoxia response, and metal-ion sensing. NDRG1 is also vital for p53-mediated caspase activation and apoptosis. Acting as a Rab4a effector, it participates in the vesicular recycling of E-cadherin. NDRG1 is ubiquitously expressed, with notable presence in placental membranes, prostate, kidney, small intestine, and ovary tissues. Adenocarcinomas exhibit reduced NDRG1 expression compared to normal tissues. Mutations in the NDRG1 gene are associated with hereditary motor and sensory neuropathy-Lom (HMSNL), a severe autosomal recessive form of Charcot-Marie-Tooth (CMT) disease. Additionally, decreased NDRG1 expression in glioma correlates with tumor progression, while its overexpression is linked to a malignant status in esophageal cancer. NDRG1 may also contribute to portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma.

A clear and sterile solution.

The antibody solution has a concentration of 1mg/ml and is prepared in a buffer containing PBS (pH 7.4), 10% Glycerol, and 0.02% Sodium Azide.

For short-term storage (up to 1 month), keep the antibody at 4°C. For long-term storage, store at -20°C. Avoid repeated freeze-thaw cycles.

The antibody remains stable for 12 months when stored at -20°C and for 1 month at 4°C.

This antibody has undergone rigorous testing in various applications, including ELISA, Western blot analysis, Flow cytometry, and ICC/IF, to ensure its specificity and reactivity. However, it is essential to optimize the antibody concentration for each specific application to achieve optimal results.

Protein NDRG1, N-myc downstream-regulated gene 1 protein, Differentiation-related gene 1 protein, Reducing agents and tunicamycin-responsive protein, Nickel-specific induction protein Cap43, DRG-1, RTP, Rit42, NDRG1, CAP43, DRG1, GC4, NDR1, NMSL, TDD5, CMT4D, HMSNL, TARG1, PROXY1.

NDRG1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.

Mouse Anti Human Monoclonal.

PAT11G4AT.

Anti-human NDRG1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human NDRG1 protein 1-394 amino acids purified from E. coli.

Mouse IgG₁ heavy chain and k light chain.