MSR1 Human, sf9
Description
Product Specs
Product Science Overview
MSR1 was first described in 1979 by Brown and Goldstein, who demonstrated that it mediated the uptake and degradation of acetylated low-density lipoprotein (acetyl-LDL) but not non-modified low-density lipoprotein (LDL) . This receptor is involved in the phagocytosis of a wide range of ligands, including modified lipoproteins, bacterial pathogens, and apoptotic cells .
The role of MSR1 in health and disease is often dichotomous, being either host-protective or detrimental to the pathogenesis of disease . For instance, MSR1 is important for M2 macrophage polarization, which is associated with anti-inflammatory responses and tissue repair . However, altered expression of MSR1 can contribute to the pathogenesis of various diseases. For example, elevated levels of MSR1 have been observed in patients with fulminant hepatitis, where it promotes neutrophil-mediated complement activation .
The recombinant expression of human MSR1 in sf9 cells (a cell line derived from the fall armyworm, Spodoptera frugiperda) is a common method used to produce this protein for research purposes . The sf9 cell line is widely used in the baculovirus expression system, which allows for high-level expression of recombinant proteins with post-translational modifications similar to those in mammalian cells .
Recombinant MSR1 produced in sf9 cells is used in various research applications, including studies on receptor-ligand interactions, the role of MSR1 in disease pathogenesis, and the development of therapeutic strategies targeting MSR1 . By understanding the molecular mechanisms influencing MSR1 expression and function, researchers can gain insights into its role in health and disease and explore potential therapeutic interventions .
