MSR1 Human
Macrophage Scavenger Receptor 1 Human Recombinant
Cat. No.
BT26554
Source
Escherichia Coli.
Synonyms
Macrophage Scavenger Receptor 1, SCARA1, Macrophage Acetylated LDL Receptor I And II, Scavenger Receptor Class A Member 1, SRA, Macrophage Scavenger Receptor Types I And II, Macrophage Scavenger Receptor Type III, Scavenger Receptor Class A, Member 1 CD204 Antigen, CD204, PhSR1, PhSR2, SR-A.
Appearance
Sterile filtered colorless solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
MSR1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 398 amino acids (77-451 a.a) and having a molecular mass of 43.7kDa.
MSR1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
MSR1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
Macrophage Scavenger Receptor 1 (MSR1), a member of the class A macrophage scavenger receptors, exists in three isoforms (1, 2, and 3) generated through alternative splicing. These macrophage-specific trimeric integral membrane glycoproteins play crucial roles in various macrophage-related physiological and pathological processes, including atherosclerosis, Alzheimer's disease, and host defense.
Description
Recombinant human MSR1, produced in E. coli, is a non-glycosylated polypeptide chain consisting of 398 amino acids (residues 77-451). With a molecular weight of 43.7 kDa, this protein contains a 23 amino acid His-tag at the N-terminus and undergoes purification using proprietary chromatographic techniques.
Physical Appearance
A clear, colorless solution that has been sterilized by filtration.
Formulation
This solution contains 0.5 mg/ml of MSR1 protein, 20 mM Tris-HCl (pH 8.0), and 10% glycerol.
Stability
For short-term storage (up to 4 weeks), keep at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freezing and thawing.
Purity
Purity exceeds 85%, as assessed by SDS-PAGE.
Synonyms
Macrophage Scavenger Receptor 1, SCARA1, Macrophage Acetylated LDL Receptor I And II, Scavenger Receptor Class A Member 1, SRA, Macrophage Scavenger Receptor Types I And II, Macrophage Scavenger Receptor Type III, Scavenger Receptor Class A, Member 1 CD204 Antigen, CD204, PhSR1, PhSR2, SR-A.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSKWETKNC SVSSTNANDI TQSLTGKGND SEEEMRFQEV FMEHMSNMEK RIQHILDMEA NLMDTEHFQN FSMTTDQRFN DILLQLSTLF SSVQGHGNAI DEISKSLISL NTTLLDLQLN IENLNGKIQE NTFKQQEEIS KLEERVYNVS AEIMAMKEEQ VHLEQEIKGE VKVLNNITND LRLKDWEHSQ TLRNITLIQG PPGPPGEKGD RGPTGESGPR GFPGPIGPPG LKGDRGAIGF PGSRGLPGYA GRPGNSGPKG QKGEKGSGNT LTPFTKVRLV GGSGPHEGRV EILHSGQWGT ICDDRWEVRV GQVVCRSLGY PGVQAVHKAA HFGQGTGPIW LNEVFCFGRE SSIEECKIRQ WGTRACSHSE DAGVTCTL
Product Science Overview
Structure and Function
MSR1 was first described in 1979 by Brown and Goldstein, who demonstrated its role in mediating the uptake and degradation of acetylated low-density lipoprotein (acetyl-LDL) . The receptor is involved in the phagocytosis of a wide range of ligands, including modified lipoproteins, apoptotic cells, and pathogens . This ability to bind and internalize diverse ligands makes MSR1 a key player in maintaining tissue homeostasis and immune response.
Role in Disease
- Atherosclerosis: MSR1 is implicated in the development of atherosclerosis by mediating the uptake of modified lipoproteins, leading to the formation of foam cells and plaque development .
- Neurodegenerative Diseases: MSR1 is expressed by microglia in the central nervous system (CNS) and is involved in the uptake and clearance of amyloid-β, a key component in Alzheimer’s disease .
- Prion Diseases: Although MSR1 expression is upregulated in prion-infected brains, studies have shown that its deficiency does not significantly affect prion disease progression or prion clearance .
- Cancer: Emerging research suggests that MSR1 plays a role in tumor-associated macrophages, influencing tumor progression and metastasis .
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