MRPS25 Antibody
Mitochondrial Ribosomal Protein S25, Mitochondrial 28S
Ribosomal Protein S25, 28S Ribosomal Protein S25 Mitochondrial, MRP-S25,
RPMS25, S25mt.
Description
Product Specs
Mitochondrial Ribosomal Protein S25, Mitochondrial 28S
Ribosomal Protein S25, 28S Ribosomal Protein S25 Mitochondrial, MRP-S25,
RPMS25, S25mt.
Product Science Overview
Mouse anti-human antibodies are antibodies produced in mice that are specific to human antigens. These antibodies are commonly used in research and diagnostic applications due to their ability to bind specifically to human proteins .
Production and Applications
Mouse anti-human antibodies are generated by immunizing mice with human antigens. The immune response in mice leads to the production of antibodies that can be harvested and purified for use . These antibodies are widely used in various assays, including enzyme-linked immunosorbent assays (ELISAs), flow cytometry, and immunohistochemistry .
Human Anti-Mouse Antibody (HAMA) Response
One challenge associated with the use of mouse anti-human antibodies is the potential for the human anti-mouse antibody (HAMA) response . This response occurs when the human immune system recognizes the mouse antibodies as foreign and mounts an immune response against them. The HAMA response can range from mild reactions, such as rashes, to severe reactions, including kidney failure . It can also interfere with the effectiveness of the antibody treatment and complicate laboratory measurements .
Advances in Antibody Engineering
To mitigate the HAMA response, advances in antibody engineering have led to the development of chimeric, humanized, and fully human antibodies . Chimeric antibodies combine mouse variable regions with human constant regions, while humanized antibodies have only the antigen-binding sites derived from mice. Fully human antibodies are produced using transgenic mice or phage display technology, reducing the likelihood of an immune response .
