MESDC2 Mouse
Description
Product Specs
Product Science Overview
MESDC2 is a monomer that interacts with several key proteins, including LRP5 and LRP6, to facilitate their proper folding and transport to the plasma membrane . This interaction is essential for the modulation of the Wnt signaling pathway, which is critical for embryonic development and cell differentiation .
The MESDC2 protein consists of 234 amino acids and has a molecular mass of approximately 26.07 kDa . It is involved in various functions, such as:
- Assisting the beta-propeller/EGF modules in folding within the family of low-density lipoprotein receptors (LPLTs).
- Acting as a modulator of the Wnt pathway by guiding the receptors LRP5 and LRP6 to the plasma membrane.
- Specifying embryonic polarity and mesoderm induction.
- Promoting cell-surface expression of LRP4, which is fundamental for neuromuscular junction (MNJ) formation .
MESDC2 is vital for the proper development of the mesoderm, one of the three primary germ layers in early embryogenesis. The mesoderm gives rise to various tissues and organs, including muscles, bones, and the circulatory system. MESDC2’s role in the Wnt signaling pathway and its interaction with LRP proteins are crucial for these developmental processes .
Recombinant MESDC2 proteins, such as the mouse recombinant version, are widely used in research to study their role in development and disease. These proteins are typically produced in laboratory settings and are available from various suppliers for use in experiments .
Researchers utilize recombinant MESDC2 to investigate its functions, interactions, and potential therapeutic applications. For example, understanding how MESDC2 modulates the Wnt pathway can provide insights into developmental disorders and diseases related to this pathway .
