MEOX2 Human
Description
Product Specs
Product Science Overview
The MEOX2 gene is located on chromosome 7p21.2 in humans . It belongs to a family of non-clustered, diverged homeobox genes. The protein encoded by MEOX2 contains a conserved homeodomain, which is a characteristic feature of homeobox proteins. This homeodomain is responsible for binding to specific DNA sequences and regulating the expression of target genes .
MEOX2 functions as a transcription factor, meaning it binds to specific DNA sequences to regulate the transcription of genes. It activates the expression of CDKN1A and CDKN2A in endothelial cells, playing a regulatory role in vascular cell proliferation . Specifically, it activates CDKN1A in a DNA-dependent manner and CDKN2A in a DNA-independent manner .
During embryogenesis, MEOX2 is expressed in a wide range of mesodermal structures, including somites, vertebrae, developing limbs, head muscles, and the developing palate . This expression pattern suggests that MEOX2 is involved in the development of craniofacial and skeletal structures .
Mutations or dysregulation of the MEOX2 gene have been associated with various developmental disorders and diseases. For example, alterations in MEOX2 expression have been linked to craniofacial and skeletal abnormalities . Additionally, MEOX2 has been implicated in vascular diseases due to its role in regulating vascular cell proliferation .
Recombinant MEOX2 protein is used in various research applications to study its function and role in development and disease. Researchers utilize recombinant MEOX2 to investigate its regulatory mechanisms and interactions with other proteins and genes. This research is crucial for understanding the molecular basis of diseases associated with MEOX2 and for developing potential therapeutic strategies.
