MEMO1 Antibody
Mediator of Cell Motility 1, Mouse Anti Human
Cat. No.
BT24861
Source
Synonyms
Protein MEMO1, C21orf19-like protein, Hepatitis C virus NS5A-transactivated protein 7, HCV NS5A-transactivated protein 7, Mediator of ErbB2-driven cell motility 1, Mediator of cell motility 1, Memo-1, MEMO1, C2orf4, MEMO, NS5ATP7, CGI-27.
Appearance
Purity
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
Product Specs
Introduction
Mediator of ErbB2-driven cell motility 1 (MEMO1), a member of the UPF0103 family, plays a crucial role in regulating cell migration. It functions by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Additionally, MEMO1 governs the cellular localization of APC and CLASP2, influencing their presence at the cell membrane through the modulation of GSK3B activity. Notably, MEMO1 is essential for the migration of breast carcinoma cells, suggesting its significance in tumor development. Furthermore, MEMO1 acts as a mediator in the ERBB2 signaling pathway.
Formulation
The antibody is supplied as a 1 mg/ml solution in phosphate-buffered saline (PBS) at pH 7.4 with 0.1% sodium azide as a preservative.
Storage Procedures
For short-term storage (up to 1 month), keep at 4°C. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Stability / Shelf Life
The antibody is stable for 12 months when stored at -20°C and for 1 month at 4°C.
Synonyms
Protein MEMO1, C21orf19-like protein, Hepatitis C virus NS5A-transactivated protein 7, HCV NS5A-transactivated protein 7, Mediator of ErbB2-driven cell motility 1, Mediator of cell motility 1, Memo-1, MEMO1, C2orf4, MEMO, NS5ATP7, CGI-27.
Purification Method
MEMO1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Type
Mouse Anti Human Monoclonal.
Clone
P1E9AT.
Immunogen
Anti-human MEMO1 mAb, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human MEMO1 amino acids 1-297 purified from E. coli.
Ig Subclass
Mouse IgG1 heavy chain and kappa light chain.
Product Science Overview
Gene and Protein Information
- Gene Symbol: MEMO1
- Chromosomal Location: Human MEMO1 is located on chromosome 2 at position 2p22.3 .
- Protein Function: MEMO1 controls cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. It is a mediator of ERBB2 signaling and plays a significant role in the stabilization of microtubules at the cell cortex . The MEMO1-RHOA-DIAPH1 signaling pathway is essential for ERBB2-dependent stabilization of microtubules .
Biological Significance
MEMO1 is involved in various biological processes, including:
- Cell Migration: MEMO1 is required for breast carcinoma cell migration and plays a role in relaying chemotactic signals to the microtubule cytoskeleton .
- ERBB2 Signaling: MEMO1 is a mediator of ERBB2 signaling, which is crucial for the stabilization of microtubules at the cell cortex .
- Microtubule Stabilization: The MEMO1-RHOA-DIAPH1 signaling pathway controls the localization of APC and CLASP2 to the cell membrane, which is required for microtubule capture and stabilization .
Mouse Model Studies
Studies on mouse models have provided significant insights into the function and phenotypes associated with MEMO1:
- Phenotypes: Mice homozygous for null alleles display strain background-dependent lethality and defects in vasculogenesis or endochondral bone development . Mice homozygous for a floxed allele activated postnatally exhibit a reduced life span, increased insulin sensitivity, small stature, graying hair, alopecia, kyphosis, loss of subcutaneous fat, loss of spermatozoa in the epididymis, and increased active vitamin D .
- Gene Expression: MEMO1 is expressed in various tissues during development, including the cardiovascular system, nervous system, and musculoskeletal system .
Antibody Information
Mouse Anti Human MEMO1 Antibody is used in research to study the expression and function of MEMO1 in human cells. This antibody is valuable for various applications, including:
- Western Blotting: To detect MEMO1 protein levels in different cell and tissue samples.
- Immunofluorescence: To visualize the localization of MEMO1 within cells.
- Immunohistochemistry: To study MEMO1 expression in tissue sections.
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