MBL2 Human, Sf9
Mannose Binding Lectin 2, Mannose-Binding Lectin (Protein C) 2, Soluble (Opsonic Defect), Collectin-1, COLEC1, MBP-C, MBP1, MBL, Mannose-Binding Lectin 2, Soluble (Opsonic Defect), Mannose-Binding Lectin (Protein C) 2, Soluble, Mannose-Binding Protein C, Mannan-Binding Protein, Mannose-Binding Lectin, Mannan-Binding Lectin, HSMBPC, MBL2D, MBPD, MBP.
Greater than 90.0% as determined by SDS-PAGE.
Description
MBL2 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 237 amino acids (21-248a.a.) and having a molecular mass of 25.1kDa. (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). MBL2 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
Mannose Binding Lectin 2, Mannose-Binding Lectin (Protein C) 2, Soluble (Opsonic Defect), Collectin-1, COLEC1, MBP-C, MBP1, MBL, Mannose-Binding Lectin 2, Soluble (Opsonic Defect), Mannose-Binding Lectin (Protein C) 2, Soluble, Mannose-Binding Protein C, Mannan-Binding Protein, Mannose-Binding Lectin, Mannan-Binding Lectin, HSMBPC, MBL2D, MBPD, MBP.
ADPETVTCED AQKTCPAVIA CSSPGINGFP GKDGRDGTKG EKGEPGQGLR GLQGPPGKLG PPGNPGPSGS PGPKGQKGDP GKSPDGDSSL AASERKALQT EMARIKKWLT FSLGKQVGNK FFLTNGEIMT FEKVKALCVK FQASVATPRN AAENGAIQNL IKEEAFLGIT DEKTEGQFVD LTGNRLTYTN WNEGEPNNAG SDEDCVLLLK NGQWNDVPCS TSHLAVCEFP IHHHHHH
Product Science Overview
Mannose-Binding Lectin 2 (MBL2) is a crucial protein in the human immune system, playing a significant role in the innate immune response. It is a member of the multimeric lectin family and is known for its ability to recognize and bind to specific carbohydrate patterns on the surface of pathogens, facilitating their clearance from the body.
MBL2 is a soluble C-type lectin produced primarily in the liver. It has an oligomeric protein structure with multiple carbohydrate recognition domains (CRDs) that bind to repetitive carbohydrate structures on the surface of pathogens . This binding triggers a series of immune responses, including complement activation, phagocytosis, and agglutination, which help in the elimination of the pathogens .
MBL2 is a key molecule in the lectin pathway of the complement system, one of the three pathways that activate the complement system. Upon binding to pathogen-associated molecular patterns (PAMPs), MBL2 activates the complement cascade, leading to the opsonization and lysis of the pathogens . This process is crucial for the first line of defense against infections, particularly in individuals with compromised adaptive immunity.
Human recombinant MBL2 is produced using the Sf9 insect cell expression system. This system is widely used for the production of recombinant proteins due to its ability to perform post-translational modifications similar to those in mammalian cells. The recombinant MBL2 produced in Sf9 cells retains its functional properties, making it suitable for research and therapeutic applications.
MBL2 gene polymorphisms are associated with varying levels of MBL2 in the blood, which can influence susceptibility to infections and autoimmune diseases . Low levels of MBL2 have been linked to an increased risk of infections, while high levels may contribute to autoimmune conditions. Recent studies have also explored the potential of MBL2 as a therapeutic target for diseases such as hepatocellular carcinoma (HCC), where increasing MBL2 levels could inhibit tumor growth and metastasis .
