MBL2 Human
Description
Product Specs
Product Science Overview
Mannose-Binding Lectin 2 (MBL2) is a crucial component of the innate immune system. It is a secreted glycoprotein that recognizes specific carbohydrate patterns on the surface of various microorganisms, including bacteria, viruses, fungi, and parasites. This recognition is essential for the activation of the classical complement pathway, which plays a significant role in the immune response against pathogens .
MBL2 is composed of multiple subunits, each consisting of three identical protein chains, forming a trimer. These trimers further assemble into higher-order oligomers, typically forming structures with two to six trimers. The protein complex is characterized by its ability to bind to mannose and N-acetylglucosamine residues on the surface of pathogens .
The primary function of MBL2 is to facilitate the opsonization and clearance of pathogens. Upon binding to the carbohydrate patterns on the pathogen surface, MBL2 activates the complement system, leading to the formation of the membrane attack complex and subsequent lysis of the pathogen. Additionally, MBL2 enhances phagocytosis by immune cells, further contributing to pathogen clearance .
The MBL2 gene is highly polymorphic, with several known variants that affect the protein’s structure, function, and serum levels. These polymorphisms can lead to varying levels of MBL2 activity among individuals, influencing their susceptibility to infections and autoimmune diseases .
Low levels of MBL2 have been associated with an increased risk of infections, particularly in individuals with compromised immune systems. Conversely, high levels of MBL2 have been linked to an increased susceptibility to certain autoimmune diseases, highlighting the complex role of MBL2 in immune regulation .
Recent research has explored the potential therapeutic applications of MBL2, particularly in the context of infectious diseases and cancer. For instance, studies have shown that increasing MBL2 levels can inhibit the growth and metastasis of hepatocellular carcinoma cells, suggesting that MBL2 could be a potential target for cancer therapy .
Furthermore, recombinant MBL2 has been investigated as a therapeutic agent to enhance immune responses in individuals with MBL2 deficiency. By supplementing with recombinant MBL2, it may be possible to restore normal immune function and reduce the risk of infections in these individuals .
