MAT2A Human
Description
MAT2A Human Recombinant fused with His tag (20 a.a.) at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 415 amino acids and having a molecular mass of 45.8 kDa.
The MAT2A is purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The MAT2A gene encodes the catalytic subunit of extrahepatic methionine adenosyltransferase (MAT II) . It is located on chromosome 2p11.2 and contains 9 exons . The gene’s promoter region is highly GC-rich and contains several potential binding sites for transcription factors such as SP1, v-myb, and GATA .
The MAT2A protein consists of 395 amino acids and shares 84% amino acid similarity with the human liver MAT I/III protein . It is expressed in various tissues, including the fetal liver, kidney, brain, testis, and lymphocytes .
MAT2A is essential for the biosynthesis of S-adenosylmethionine (SAMe), which is the major methyl donor for many transmethylation reactions in the body . SAMe also participates in the transsulfuration pathway and serves as a propylamine group donor in the biosynthesis of polyamines . These processes are vital for cellular growth, differentiation, and overall metabolic regulation .
MAT2A expression is associated with growth, dedifferentiation, and cancer in the liver . It has been observed that low-dose gamma irradiation can increase the expression of MAT2A and its associated long noncoding RNA PARTICLE . This suggests potential roles in radiation response and cancer biology .
