MAPK10 Human
Sf9, Baculovirus cells.
C-Jun N-Terminal Kinase 3, MAP Kinase P49 3F12, MAP Kinase 10, PRKM10, SAPK1b, JNK3A, JNK3.
Greater than 85.0% as determined by SDS-PAGE.
Description
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MAPK10 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 470 amino acids (1-464 a.a.) and having a molecular mass of 53.4kDa. |
MAPK10 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
C-Jun N-Terminal Kinase 3, MAP Kinase P49 3F12, MAP Kinase 10, PRKM10, SAPK1b, JNK3A, JNK3.
Sf9, Baculovirus cells.
MSLHFLYYCS EPTLDVKIAF CQGFDKQVDV SYIAKHYNMS KSKVDNQFYS VEVGDSTFTV LKRYQNLKPI GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH KNIISLLNVF TPQKTLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL YQMLCGIKHL HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY KENVDIWSVG CIMGEMVRHK ILFPGRDYID QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN RPKYAGLTFP KLFPDSLFPA DSEHNKLKAS QARDLLSKML VIDPAKRISV DDALQHPYIN VWYDPAEVEA PPPQIYDKQL DEREHTIEEW KELIYKEVMN SEEKTKNGVV KGQPSPSGAA VNSSESLPPS SSVNDISSMS TDQTLASDTD SSLEASAGPL GCCRHHHHHH.
Product Science Overview
Mitogen-Activated Protein Kinase 10 (MAPK10), also known as c-Jun N-terminal kinase 3 (JNK3), is a member of the MAP kinase family. This family of kinases plays a crucial role in various cellular processes, including proliferation, differentiation, transcription regulation, and development. MAPK10 is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation .
The MAPK10 gene is located on chromosome 4 and encodes a protein that is part of the c-Jun N-terminal kinases (JNK) subgroup within the MAPK superfamily . The protein is a serine/threonine-specific kinase involved in various processes such as neuronal proliferation, differentiation, migration, and programmed cell death .
MAPK10 acts as an integration point for multiple biochemical signals, making it essential for various cellular responses. It is particularly significant in the nervous system, where it is involved in stress-induced neuronal apoptosis . The kinase is activated by extracellular stimuli such as pro-inflammatory cytokines or physical stress, which stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway .
MAPK10 has been implicated in several diseases, including Lennox-Gastaut Syndrome and Developmental and Epileptic Encephalopathy 94 . Recent studies have also suggested that MAPK10 may function as a tumor suppressor in hepatocellular carcinoma (HCC). The protein expression of MAPK10 is significantly downregulated in clinical samples of HCC patients compared to adjacent normal tissues . This downregulation is often due to epigenetic modifications such as methylation, which silences the gene .
The role of MAPK10 in various diseases makes it a potential target for therapeutic interventions. For instance, reversing the methylation of MAPK10 in HCC cell lines has been shown to inhibit colony formation, induce apoptosis, and enhance chemosensitivity to 5-fluorouracil . These findings suggest that MAPK10 could be a valuable biomarker or therapeutic target in clinical settings .
