MAP2K3 Human

MAP2K3 is a dual-specificity threonine/tyrosine protein kinase. It is activated by mitogenic and environmental stress and participates in the MAP kinase-mediated signaling cascade. Upon activation, MAP2K3 phosphorylates and activates MAPK14/p38-MAPK . This activation is crucial for the regulation of several biological processes, including inflammation and cellular stress responses .

MAP2K3 can be activated by various stimuli, including insulin and environmental stressors . It plays a significant role in the expression of glucose transporters, which are essential for cellular glucose uptake . Additionally, MAP2K3 is involved in the regulation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways . These pathways are vital for cellular responses to stress and inflammatory stimuli.

The activation of MAP2K3 leads to the phosphorylation of downstream targets, which in turn regulate various cellular processes. For instance, the activation of MAPK14/p38-MAPK by MAP2K3 is essential for the cellular response to stress and inflammation . This pathway also plays a role in the regulation of apoptosis, cell cycle progression, and differentiation.

Mutations or dysregulation of MAP2K3 have been associated with various diseases, including cancer and inflammatory disorders . Understanding the role of MAP2K3 in these diseases can provide insights into potential therapeutic targets. For example, targeting MAP2K3 with specific inhibitors could be a strategy for treating diseases characterized by excessive inflammation or uncontrolled cell proliferation.

Recombinant MAP2K3 is a form of the protein that is produced through recombinant DNA technology. This technology allows for the production of large quantities of the protein, which can be used for research and therapeutic purposes. Recombinant MAP2K3 is used in various studies to understand its function and regulation, as well as to develop potential therapeutic interventions.