LTA Antibody

LT-α is a member of the tumor necrosis factor (TNF) superfamily. Unlike other members of this family, LT-α is found only as a soluble homotrimer or as a heterotrimer with LTβ when at the cell surface . This protein is involved in various biological processes, including:

• Positive regulation of chronic inflammatory response to antigenic stimulus
• Response to hypoxia and nutrient levels
• Cell-cell signaling
• Positive regulation of humoral immune response mediated by circulating immunoglobulin
• Positive regulation of interferon-gamma production
• Tumor necrosis factor-mediated signaling pathway
• Response to lipopolysaccharide
• Immune response and apoptotic processes

LT-α is expressed in various tissues, including the spleen, thymus, and lymph nodes . Its absence can lead to significant disruptions in gastrointestinal development, prevent Peyer’s patch development, and result in a disorganized spleen .

Mouse anti-human LT-α antibodies are monoclonal antibodies derived from the hybridization of mouse myeloma cells with spleen cells from BALB/c mice immunized with recombinant human LT-α . These antibodies are used in various research applications, including the study of immune responses and the development of therapeutic interventions.

In a human peripheral blood mononuclear cell transplanted SCID mouse model of graft-versus-host disease (GVHD), anti-human LT-α monoclonal antibodies specifically depleted activated LT-α-expressing human donor T and B cells, resulting in prolonged survival of the mice .

LT-α has been studied extensively for its role in immune regulation and its potential therapeutic applications. For example, chronic overexpression of LT-α in the cerebral meninges has been shown to induce lymphoid-like structures and neurodegeneration, similar to that seen in progressive multiple sclerosis . This highlights the importance of LT-α in both normal immune function and pathological conditions.