LITAF Antibody

Lipopolysaccharide-induced Tumor Necrosis Factor (TNF) factor, often referred to as LITAF, is a protein that plays a crucial role in the immune response. This protein is particularly significant in the context of inflammation and immune system activation. The “Mouse Anti Human” designation indicates that this is an antibody derived from mice that targets the human version of the LITAF protein.

Lipopolysaccharides are large molecules found in the outer membrane of Gram-negative bacteria. They are known to trigger strong immune responses in animals. When LPS binds to receptors on immune cells, it can induce the production of various cytokines, including TNF-α, which is a key mediator of inflammation .

TNF is a cytokine involved in systemic inflammation and is part of the body’s acute phase reaction. It is produced primarily by macrophages and can induce fever, apoptotic cell death, sepsis (through IL-1 & IL-6 production), and inflammation . TNF-α is the most well-known member of this family and is a major target for anti-inflammatory drugs.

The LITAF protein is involved in the regulation of TNF-α production. It is a transcription factor that can bind to the promoter regions of TNF-α genes, thereby enhancing their expression in response to inflammatory stimuli such as LPS . This makes LITAF a critical component in the pathway that leads to the production of TNF-α during an immune response.

The “Mouse Anti Human” designation refers to an antibody produced in mice that is specific for the human version of the LITAF protein. These antibodies are often used in research to study the function of LITAF in human cells. They can be used in various assays, including Western blotting, immunohistochemistry, and flow cytometry, to detect the presence and quantify the levels of LITAF in human samples .

The study of LITAF and its role in TNF-α production is crucial for understanding the mechanisms of inflammation and immune response. Researchers use mouse anti-human LITAF antibodies to investigate how LITAF regulates TNF-α production and how this regulation affects various diseases, including autoimmune disorders, infections, and cancer . By understanding these mechanisms, scientists can develop new therapeutic strategies to modulate the immune response and treat inflammatory diseases.