LGALS9 Mouse
Description
LGALS9 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Galectin-9 is a member of the galectin family, which comprises multifunctional carbohydrate-binding proteins with specificity for N-acetyl-lactosamine-containing glycoproteins. Galectins are involved in various biological processes, including cell-cell adhesion, cell-matrix interactions, and immune response modulation. Galectin-9, in particular, has garnered significant interest due to its diverse roles in immune regulation and potential therapeutic applications.
Galectin-9 is a tandem-repeat type galectin, meaning it contains two carbohydrate recognition domains (CRDs) connected by a linker region . The full-length Galectin-9 protein is approximately 39 kDa in size. Alternative splicing of the Galectin-9 gene can generate different isoforms, including a small intestine-specific isoform with a 31 amino acid insertion in the linker region .
Galectin-9 is widely expressed in various tissues, including the thymus, spleen, liver, and gastrointestinal tract. It plays a crucial role in modulating immune responses, particularly in the context of T-cell regulation. Galectin-9 can induce apoptosis in T-cells, thereby contributing to the maintenance of immune homeostasis and the prevention of autoimmune diseases .
In addition to its immunomodulatory functions, Galectin-9 has been implicated in various pathological conditions, including cancer, infectious diseases, and inflammatory disorders. For instance, it has been shown to inhibit the proliferation of certain cancer cells and enhance the immune response against tumors .
Recombinant Mouse Galectin-9 is produced using E. coli expression systems. The recombinant protein typically includes the amino acid sequence from Ala2 to Thr322, with a predicted molecular mass of approximately 36.4 kDa . The protein is purified to a high degree of purity (>95%) and is free from endotoxins, making it suitable for various research applications .
Recombinant Mouse Galectin-9 is widely used in research to study its biological functions and potential therapeutic applications. Some of the key applications include:
- Immune Regulation Studies: Investigating the role of Galectin-9 in modulating immune responses, particularly in T-cell apoptosis and immune tolerance.
- Cancer Research: Exploring the anti-tumor effects of Galectin-9 and its potential as a therapeutic agent in cancer treatment.
- Infectious Disease Research: Studying the role of Galectin-9 in host-pathogen interactions and its potential as a therapeutic target in infectious diseases.
- Inflammatory Disorders: Investigating the involvement of Galectin-9 in inflammatory processes and its potential as a therapeutic target in inflammatory diseases .
