LGALS2 Mouse

Galectin-2 is an approximately 14 kDa homodimeric protein belonging to the S-type lectin family . It consists of a single carbohydrate-recognition domain (CRD), which is responsible for its binding to specific carbohydrate structures . The mouse Galectin-2 shares 86% and 66% amino acid sequence identity with rat and human Galectin-2, respectively .

Galectin-2 plays a significant role in modulating immune responses. It is known to induce a proinflammatory, anti-arteriogenic phenotype in monocytes and macrophages . This means that Galectin-2 can promote inflammation and inhibit the formation of new blood vessels, which is particularly relevant in the context of cardiovascular diseases . The protein exerts its effects through the CD14/toll-like receptor (TLR)-4 pathway, influencing the behavior of monocytes and macrophages .

Recombinant mouse Galectin-2 is widely used in research to study its biological functions and potential therapeutic applications. It is produced using human embryonic kidney cell (HEK293)-derived systems, ensuring high purity and activity . The recombinant protein is often used in experiments to understand its role in immune modulation, cell adhesion, and its potential as a therapeutic target in inflammatory and cardiovascular diseases .

Recombinant mouse Galectin-2 is typically lyophilized and should be reconstituted in water before use . It is recommended to store the protein at -20 to -70°C to maintain its stability and avoid repeated freeze-thaw cycles . Once reconstituted, it can be stored under sterile conditions at 2 to 8°C for up to one month or at -20 to -70°C for up to three months .