KLRD1 Human

KLRD1 is classified as a type II membrane protein due to its external C terminus . The gene is located on chromosome 12 in humans and has several transcript variants encoding different isoforms . The protein encoded by KLRD1 is a lectin and a receptor involved in cell signaling, expressed on the surface of NK cells .

KLRD1 is primarily involved in the regulation of NK cell function. NK cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation . KLRD1, in complex with KLRC1 or KLRC2, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia and non-classical MHC class Ib molecules . This enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self .

KLRD1 is associated with several diseases, including mucinous cystadenofibroma and cystadenofibroma . It is also involved in pathways related to the innate immune system and DAP12 interactions . The protein’s ability to bind to MHC class I protein complexes and its role in transmembrane signaling receptor activity are crucial for immune response regulation .

The recombinant form of KLRD1 is used in various research applications to study its function and interactions. Understanding the role of KLRD1 in immune response can lead to advancements in immunotherapy and treatments for diseases involving the immune system .