KLF3 Human

KLF3 was the third member of the Kruppel-like factor family to be discovered. It is a transcription factor that plays a crucial role in various cellular processes, including cell growth, proliferation, differentiation, and embryogenesis . The protein is composed of 345 amino acids and has a molecular weight of approximately 41.2 kDa .

KLF3 functions as a transcriptional repressor and is involved in the regulation of gene expression by binding to specific DNA sequences. It has been shown to play a role in hematopoiesis, the process by which blood cells are formed . Additionally, KLF3 is implicated in the regulation of angiogenesis, the formation of new blood vessels, through its interaction with other proteins and transcription factors .

Recombinant KLF3 is produced using an expression system, typically in E. coli, and is often tagged with a His-tag at the N-terminus to facilitate purification . The recombinant protein is used in various research applications, including blocking assays and control experiments . It is supplied in a purified form and is stored under specific conditions to maintain its stability and activity .

Recombinant KLF3 is widely used in research to study its role in gene regulation and its interactions with other proteins. It is also used in experiments to understand its function in hematopoiesis and angiogenesis . The protein’s ability to bind to DNA and regulate gene expression makes it a valuable tool for investigating the molecular mechanisms underlying various biological processes.