KIR2DL4 Human
Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 4,Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail 4,Killer Cell Inhibitory Receptor 103AS, MHC Class I NK Cell Receptor KIR103AS,CD158 Antigen-Like Family Member D, KIR-103AS, KIR103AS, CD158D, G9P, Killer Cell Immunoglobulin-Like Receptor 2DL4, CD158d Antigen, KIR-2DL4, KIR103, KIR2DL4.
Greater than 85.0% as determined by SDS-PAGE.
Description
KIR2DL4 Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 458 amino acids (24-242 a.a.) and having a molecular mass of 51kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa). KIR2DL4 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 4,Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail 4,Killer Cell Inhibitory Receptor 103AS, MHC Class I NK Cell Receptor KIR103AS,CD158 Antigen-Like Family Member D, KIR-103AS, KIR103AS, CD158D, G9P, Killer Cell Immunoglobulin-Like Receptor 2DL4, CD158d Antigen, KIR-2DL4, KIR103, KIR2DL4.
HVGGQDKPFC SAWPSAVVPQ GGHVTLRCHY RRGFNIFTLY KKDGVPVPEL YNRIFWNSFL ISPVTPAHAG TYRCRGFHPH SPTEWSAPSN PLVIMVTGLY EKPSLTARPG PTVRAGENVT LSCSSQSSFD IYHLSREGEA HELRLPAVPS INGTFQADFP LGPATHGETY RCFGSFHGSP
YEWSDPSDPL PVSVTGNPSS SWPSPTEPSF KTGIARHLHL EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR
DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH
Product Science Overview
Killer Cell Immunoglobulin-Like Receptor, Two Domains Long Cytoplasmic Tail 4 (KIR2DL4) is a protein encoded by the KIR2DL4 gene. This receptor is part of the larger family of killer cell immunoglobulin-like receptors (KIRs), which are transmembrane glycoproteins expressed primarily by natural killer (NK) cells and certain subsets of T cells .
The KIR2DL4 gene is located on chromosome 19q13.4 within the leukocyte receptor complex (LRC), a region known for its high density of immune-related genes . The gene encodes a protein that consists of 378 amino acids . The structure of KIR2DL4 includes:
- Two extracellular immunoglobulin-like domains: These domains are involved in the recognition of specific ligands.
- A transmembrane domain: This hydrophobic region anchors the receptor in the cell membrane.
- A long cytoplasmic tail: The cytoplasmic tail contains two immunoreceptor tyrosine-based inhibitory motifs (ITIMs), which are crucial for transmitting inhibitory signals within the cell .
KIR2DL4 plays a significant role in the regulation of NK cell activity. NK cells are a critical component of the innate immune system, responsible for identifying and destroying virally infected cells and tumor cells. The primary function of KIR2DL4 is to recognize specific human leukocyte antigen (HLA) class I molecules, particularly HLA-G .
Upon binding to its ligand, KIR2DL4 transmits inhibitory signals through its ITIMs. These signals recruit intracellular protein tyrosine phosphatases, such as SHP-1, which dephosphorylate key signaling molecules, ultimately leading to the inhibition of NK cell cytotoxic activity .
KIR2DL4 has been implicated in various clinical conditions. For instance, its interaction with HLA-G is thought to play a role in maternal-fetal tolerance during pregnancy. Abnormal expression or function of KIR2DL4 has been associated with complications such as preeclampsia and recurrent spontaneous abortions .
Additionally, KIR2DL4 is involved in the immune response to certain infections and cancers. Variations in the KIR2DL4 gene and its expression levels have been linked to differences in susceptibility to diseases such as graft-versus-host disease and certain autoimmune disorders .
