IRF7 Antibody
Description
Product Specs
Product Science Overview
Interferon Regulatory Factor-7 (IRF7) is a member of the interferon regulatory transcription factor (IRF) family. It plays a crucial role in the transcriptional activation of virus-inducible cellular genes, including type I interferon genes . IRF7 is essential for the production of type I interferons (IFN-I), which are critical components of the innate immune response against viral infections .
IRF7 contains a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the IRF-element (IRF-E) motifs located upstream of the interferon genes . The C-terminal regions of IRF7 are diverse and related to distinct functions, containing two types of IRF-associated domains (IADs) that mediate interactions with other IRF members, transcription factors, or cofactors .
IRF7 is predominantly expressed in the cytoplasm of the spleen, thymus, and peripheral blood lymphocytes, such as B cells, plasmacytoid dendritic cells (pDCs), and monocytes . It is activated by signaling cascades from pathogen recognition receptors (PRRs) that recognize pathogenic nucleic acids . Upon activation, IRF7 translocates to the nucleus, where it binds to IRF-E motifs and activates the transcription of type I IFNs .
Mouse Anti Human IRF7 antibodies are used in research to study the expression and function of IRF7 in human cells. These antibodies are typically generated by immunizing mice with human IRF7 protein, leading to the production of antibodies that specifically recognize and bind to human IRF7. These antibodies are valuable tools for investigating the role of IRF7 in various biological processes, including immune response, inflammation, and cancer .
IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes . It is involved in the regulation of many interferon-alpha genes and is essential for the production of type I interferons . IRF7 is also implicated in the regulation of immune responses, including the positive regulation of type I interferon-mediated signaling pathways and the response to viral infections .
