ING2 Antibody

The Inhibitor of Growth (ING) family consists of tumor suppressor genes that play crucial roles in regulating cell proliferation, apoptosis, and cellular senescence. The family includes five members: ING1, ING2, ING3, ING4, and ING5. These genes are highly conserved across species, including humans and mice .

The ING2 gene encodes a protein that is involved in various cellular processes, including DNA repair, apoptosis, and chromatin remodeling. The ING2 protein is known to interact with histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes, which are essential for regulating gene expression through epigenetic mechanisms .

ING2, like other members of the ING family, functions as a tumor suppressor. It is involved in the activation of the p53 pathway, which is crucial for inducing apoptosis in response to DNA damage. The loss or mutation of ING2 has been associated with various types of cancer, highlighting its importance in maintaining cellular homeostasis and preventing malignant transformation .

The mouse anti-human ING2 antibody is a monoclonal antibody used in research to study the expression and function of the ING2 protein in human cells. This antibody is valuable for various applications, including Western blotting, immunohistochemistry, and immunoprecipitation. By targeting the ING2 protein, researchers can gain insights into its role in different cellular processes and its involvement in cancer development .