Influenza B Antibody

Influenza-B Jiangsu/10/2003 Hemagglutinin, Rabbit Antibody
Cat. No.
BT4648
Source
Synonyms
Appearance
Purity
90%.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs
In Stock
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Description

Influenza Hemagglutinin protein is an envelope glycoprotein responsible for binding to sialic receptors and influenza viral entry into host cells. The antibody was produced by immunization of rabbits with purified recombinant influenza B Jiangsu/10/2003 Virus produced in insect cells using baculovirus expression vector system. The antigen was purified under conditions that preserve the HA proteins biological activity and tertiary structure.

Product Specs

Introduction
Influenza B virus, a member of the Orthomyxoviridae family, is a significant human pathogen. Unlike influenza A virus with its wide host range, influenza B virus primarily infects humans and seals. This limited host range contributes to its slower evolutionary rate compared to influenza A. While influenza B virus evolves slower, it still undergoes genetic changes, including drift and reassortment, at a rate that prevents long-lasting immunity. The virus structure includes a segmented RNA genome, an envelope, and surface proteins like hemagglutinin and neuraminidase crucial for its infectivity.
Description
The Influenza Hemagglutinin protein is a key surface glycoprotein of the influenza B virus, playing a critical role in the virus's ability to attach to host cells. This antibody, targeting the hemagglutinin protein, was generated by immunizing rabbits with a purified recombinant form of the protein derived from the influenza B Jiangsu/10/2003 strain. The recombinant protein, produced using a baculovirus expression system in insect cells, was purified under stringent conditions to maintain its structural integrity and biological activity.
Purity
Greater than 90%
Formulation

Phosphate-buffered saline (PBS) with a pH of 7.0, containing 0.005% sodium azide as a preservative, and 50% glycerol as a stabilizing agent.

Shipping Conditions
To ensure stability during transport, the antibody is shipped in liquid form packaged with ice packs to maintain a low temperature.
Storage Procedures
Upon receipt, the antibody should be stored at a temperature of -20 degrees Celsius to maintain its long-term stability and activity.
Applications
This influenza B hemagglutinin antibody has been validated for use in Western Blotting at a concentration of 0.5 micrograms per milliliter. Its efficacy in ELISA applications is currently under evaluation.
Type
Rabbit Antibody Polyclonal.
Immunogen
Recombinant Influenza B Jiangsu/10/2003.

Product Science Overview

Introduction

The Influenza-B Jiangsu/10/2003 Hemagglutinin, Rabbit Antibody is a polyclonal antibody produced by immunizing rabbits with the hemagglutinin protein from the Influenza B virus strain Jiangsu/10/2003. This antibody is widely used in research for its high specificity and affinity towards the hemagglutinin protein, which plays a crucial role in the virus’s ability to infect host cells.

Influenza B Virus and Hemagglutinin

Influenza B virus (IBV) is a member of the Orthomyxoviridae family and is one of the primary causes of seasonal flu epidemics. Unlike Influenza A, which can infect multiple species, Influenza B primarily infects humans. The hemagglutinin (HA) protein is an envelope glycoprotein responsible for binding to sialic acid receptors on the surface of host cells, facilitating viral entry .

Jiangsu/10/2003 Strain

The Jiangsu/10/2003 strain of Influenza B was isolated in Jiangsu, China, in 2003. This strain is significant for its unique antigenic properties, which make it a valuable target for antibody production and research. The hemagglutinin protein from this strain has been extensively studied to understand its structure and function, as well as its role in viral infectivity and immune response.

Production of Rabbit Antibody

The rabbit antibody against Influenza-B Jiangsu/10/2003 hemagglutinin is produced by immunizing rabbits with the purified recombinant hemagglutinin protein. The immune system of the rabbit recognizes the hemagglutinin as a foreign antigen and produces antibodies against it. These antibodies are then harvested and purified for use in various research applications .

Applications

The Influenza-B Jiangsu/10/2003 Hemagglutinin, Rabbit Antibody is used in several research applications, including:

  • ELISA (Enzyme-Linked Immunosorbent Assay): To detect the presence of hemagglutinin in samples.
  • Western Blotting: To identify and quantify hemagglutinin protein in a mixture of proteins.
  • Immunohistochemistry: To visualize the localization of hemagglutinin in tissue samples.
  • Flow Cytometry: To analyze the expression of hemagglutinin on the surface of cells .

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