Influenza B Malaysia
Description
Product Specs
Product Science Overview
Influenza B virus is a member of the Orthomyxoviridae family, which also includes Influenza A and C viruses. Unlike Influenza A, which infects a variety of vertebrate hosts, Influenza B primarily infects humans and is less common and less severe in terms of disease impact . The Influenza B virus is divided into two major lineages: B/Victoria/2/87-like and B/Yamagata/16/88-like .
The Influenza B/Malaysia/2506/2004 strain was isolated in Malaysia in 2004 . This strain is part of the B/Victoria lineage and has been used in various research and vaccine development efforts. The strain is known for its hemagglutinin (HA) protein, which plays a crucial role in the virus’s ability to infect host cells .
Recombinant proteins from the Influenza B/Malaysia/2506/2004 strain are widely used in research. These proteins are produced in different expression systems, such as baculovirus-insect cells and HEK293 cells . The hemagglutinin (HA) protein, in particular, is a key target for vaccine development and immunological studies .
The evolutionary dynamics of Influenza B viruses are influenced by antigenic drift and reassortment events. These processes generate genetic diversity and help the virus evade host immune responses . The B/Malaysia/2506/2004 strain has contributed to our understanding of these evolutionary mechanisms, particularly in the context of the B/Victoria lineage .
The B/Malaysia/2506/2004 strain has been used in the development of inactivated vaccines. These vaccines are produced by growing the virus in embryonated chicken eggs, followed by inactivation and purification processes . The inactivated virus is then formulated into vaccines that are tested for safety and efficacy .
