IL32 Antibody

Interleukin-32 (IL-32) is a cytokine that was first identified in 1992 from natural killer cells and was originally named natural killer cell transcript 4 (NK4) . It has since been recognized as an important immunoregulatory molecule involved in various biological processes and diseases.

IL-32 exists in multiple isoforms, including IL-32α, IL-32β, IL-32γ, IL-32δ, IL-32ϵ, IL-32ζ, and IL-32θ . These isoforms are produced through alternative splicing of the IL-32 gene and exhibit different biological activities. Among these, IL-32θ has been found to possess the most dominant biological activity .

IL-32 plays a crucial role in the regulation of immune responses. It is involved in the production of various inflammatory cytokines, such as IL-8 and tumor necrosis factor-alpha (TNF-α) . IL-32 can influence cell differentiation and cell death, and it is involved in both anti-inflammatory and pro-inflammatory processes . The cytokine can exert its effects through both extracellular and intracellular pathways, although the specific receptors for IL-32 have not yet been fully identified .

IL-32 has been implicated in the pathogenesis of several diseases, including autoimmune diseases, inflammatory diseases, certain types of cancer, and infectious diseases . For example, IL-32 has been shown to play a role in asthma, where it can modulate the inflammatory response in the airways . Additionally, high levels of IL-32 expression have been observed in various tissues affected by different diseases .

Mouse anti-human IL-32 antibodies are commonly used in research to study the expression and function of IL-32 in human tissues. These antibodies are generated by immunizing mice with human IL-32 protein, leading to the production of antibodies that specifically recognize and bind to human IL-32. These antibodies are valuable tools for investigating the role of IL-32 in various biological processes and diseases.