IL2RG Human

Interleukin-2 Receptor Gamma Human Recombinant
Cat. No.
BT13085
Source
Sf9, Baculovirus cells.
Synonyms
Interleukin 2 Receptor Gamma, IL-2 Receptor Subunit Gamma, IL-2R Subunit Gamma, CD132 Antigen, SCIDX1, IL-2RG, GammaC, SCIDX, IMD4, P64, Cytokine Receptor Common Subunit Gamma, Common Cytokine Receptor Gamma Chain, Interleukin-2 Receptor Subunit Gamma, Combined Immunodeficiency X-Linked, Severe Combined Immunodeficiency, CD132, CIDX, IL2RG.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 80.0% by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

IL2RG Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 246 amino acids (23-262 a.a.) and having a molecular mass of 29kDa (Migrates at 40-57kDa on SDS-PAGE under reducing conditions).
IL2RG is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Product Specs

Introduction
The interleukin-2 receptor gamma (IL2RG) is a subunit found within the receptor complexes of at least six different interleukin receptors. This subunit is crucial for immune system function, as it facilitates the development and maturation of lymphocytes, which are essential for defending the body against infections and diseases. IL2RG is located on the surface of immature blood-forming cells in the bone marrow. It binds to cytokines outside the cell and transmits signals to the cell's nucleus, guiding the differentiation of blood-forming cells into lymphocytes. Additionally, IL2RG plays a role in directing the growth and maturation of lymphocyte subtypes, including those responsible for destroying viruses, producing antibodies, and regulating the overall immune response.
Description
Recombinant human IL2RG, produced in Sf9 Baculovirus cells, is a single, glycosylated polypeptide chain with a molecular weight of 29 kDa (observed as 40-57 kDa on SDS-PAGE under reducing conditions). This protein consists of 246 amino acids (23-262 a.a.), including a 6-amino acid His tag at the C-terminus. Purification is achieved through proprietary chromatographic techniques.
Physical Appearance
A clear, sterile-filtered solution.
Formulation
The IL2RG protein solution is provided at a concentration of 0.5 mg/ml in phosphate-buffered saline (pH 7.4).
Stability
For short-term storage (2-4 weeks), the solution should be kept at 4°C. For extended storage, it is recommended to freeze the solution at -20°C. To enhance stability during long-term storage, consider adding a carrier protein such as HSA or BSA (0.1%). Avoid repeated freeze-thaw cycles to maintain protein integrity.
Purity
The purity of the protein is determined to be greater than 80.0% as assessed by SDS-PAGE analysis.
Synonyms
Interleukin 2 Receptor Gamma, IL-2 Receptor Subunit Gamma, IL-2R Subunit Gamma, CD132 Antigen, SCIDX1, IL-2RG, GammaC, SCIDX, IMD4, P64, Cytokine Receptor Common Subunit Gamma, Common Cytokine Receptor Gamma Chain, Interleukin-2 Receptor Subunit Gamma, Combined Immunodeficiency X-Linked, Severe Combined Immunodeficiency, CD132, CIDX, IL2RG.
Source
Sf9, Baculovirus cells.
Amino Acid Sequence
LNTTILTPNG NEDTTADFFL TTMPTDSLSV STLPLPEVQC FVFNVEYMNC TWNSSSEPQP TNLTLHYWYK NSDNDKVQKC SHYLFSEEIT SGCQLQKKEI HLYQTFVVQL QDPREPRRQA TQMLKLQNLV IPWAPENLTL HKLSESQLEL NWNNRFLNHC LEHLVQYRTD WDHSWTEQSV DYRHKFSLPS VDGQKRYTFR VRSRFNPLCG SAQHWSEWSH PIHWGSNTSK ENPFLFALEA HHHHHH.

Product Science Overview

Introduction

Interleukin-2 Receptor Gamma (IL-2Rγ), also known as the common gamma chain (γc), is a crucial component of the immune system. This protein is encoded by the IL2RG gene and is a part of several cytokine receptors, including those for interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-7 (IL-7), interleukin-9 (IL-9), interleukin-15 (IL-15), and interleukin-21 (IL-21) . The common gamma chain is essential for the proper functioning of these receptors, which play significant roles in the regulation and development of immune cells.

Structure and Function

The IL-2Rγ is a transmembrane protein that spans the cell membrane, with one end outside the cell acting like an antenna to receive signals and the other end inside the cell to transmit these signals to the nucleus . This signaling is vital for the proliferation, differentiation, and survival of various immune cells, including T cells, B cells, and natural killer (NK) cells.

Recombinant IL-2Rγ

Recombinant IL-2Rγ is a laboratory-produced version of the natural protein. It is created using recombinant DNA technology, which involves inserting the IL2RG gene into a suitable expression system, such as bacteria, yeast, or mammalian cells. This allows for the large-scale production of the protein, which can then be purified and used for research or therapeutic purposes.

Clinical Significance

Mutations in the IL2RG gene can lead to severe combined immunodeficiency (SCID), a condition characterized by a severely compromised immune system . Patients with SCID are highly susceptible to infections and require prompt medical intervention, often including bone marrow transplantation. Recombinant IL-2Rγ can be used in research to study the function of the protein and to develop potential therapies for conditions related to its dysfunction.

Applications in Research and Medicine

Recombinant IL-2Rγ is used in various research applications to understand its role in immune signaling and to develop new treatments for immune-related disorders. It is also being explored as a potential therapeutic agent in cancer immunotherapy, where it can help enhance the body’s immune response against cancer cells .

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