IL13RA2 Human, Sf9
CD213A2, CT19, IL-13R, IL13BP, IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, CD_antigen=CD213a2, Interleukin-13-binding protein.
Greater than 85.0% as determined by SDS-PAGE.
Description
IL13RA2 Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 559 amino acids (27-343 a.a.) and having a molecular mass of 64.3kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa). IL13RA2 is expressed with a 239 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
CD213A2, CT19, IL-13R, IL13BP, IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, CD_antigen=CD213a2, Interleukin-13-binding protein.
ADLDTEIKVN PPQDFEIVDP GYLGYLYLQW QPPLSLDHFK ECTVEYELKY RNIGSETWKT IITKNLHYKD GFDLNKGIEA KIHTLLPWQC TNGSEVQSSW AETTYWISPQ GIPETKVQDM DCVYYNWQYL LCSWKPGIGV LLDTNYNLFY WYEGLDHALQ CVDYIKADGQ NIGCRFPYLE ASDYKDFYIC VNGSSENKPI RSSYFTFQLQ NIVKPLPPVY LTFTRESSCE IKLKWSIPLG PIPARCFDYE IEIREDDTTL VTATVENETY TLKTTNETRQ LCFVVRSKVN IYCSDDGIWS EWSDKQCWEG EDLSKKTLLR LEPKSCDKTH TCPPCPAPEL LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS RDELTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN
HYTQKSLSLS PGKHHHHHH
Product Science Overview
Interleukin 13 Receptor Alpha 2 (IL-13Rα2) is a protein that plays a significant role in the immune system. It is part of the type I cytokine receptor family and is closely related to IL-13Rα1, another subunit of the interleukin 13 receptor complex . Recombinant Human IL-13Rα2 produced in Sf9 cells is used in various research and therapeutic applications.
Interleukin-13 (IL-13) is an immune regulatory cytokine involved in allergy and atopic diseases . IL-13 has two receptors: IL-13Rα1 and IL-13Rα2. While IL-13Rα1 binds IL-13 with low affinity and mediates IL-13 cellular functions by pairing with IL-4 receptor (IL-4R)α, IL-13Rα2 binds IL-13 with high affinity but does not mediate IL-13 cellular functions due to its short cytoplasmic tail and lack of signaling motifs . The cDNA for IL-13Rα2 was first isolated from human renal carcinoma cell lines in 1996 .
IL-13Rα2 is often regarded as a decoy receptor because it prevents the binding of IL-13 to IL-13Rα1, thereby inhibiting IL-13 signaling when overexpressed . However, recent studies have shown that IL-13Rα2 may have IL-13-dependent and IL-13-independent functions, indicating that it might be more than just a decoy receptor . IL-13Rα2 is also known as cancer/testis antigen 19 (CT19) due to its increased expression in high-grade cancers such as glioblastoma .
IL-13Rα2 is narrowly expressed in human tissues, with mRNA expression found in the placenta, testis, liver, lung, thymus, and brain . In mice, the IL-13Rα2 transcript has been found in the spleen, liver, bone marrow, brain, colon, and skin . IL-13Rα2 is highly expressed in several cancers, including glioblastoma, ovarian carcinoma, breast cancer, prostate cancer, pancreatic cancer, and Kaposi’s sarcoma . The expression of IL-13Rα2 can be stimulated by allergens or Th2 cytokines .
Recombinant Human IL-13Rα2 produced in Sf9 cells is used in research to study its functions and potential therapeutic applications. Sf9 cells, derived from the fall armyworm Spodoptera frugiperda, are commonly used for the production of recombinant proteins. The recombinant IL-13Rα2 produced in these cells retains its binding affinity for IL-13 and is used in various assays to understand its role in immune regulation and cancer .
