IL 20 Mouse

Recombinant Mouse IL-20 is typically produced in E. coli cells . The protein has a predicted molecular weight of approximately 17 kDa and is often lyophilized for stability . The amino acid sequence for Mouse IL-20 spans from Leu25 to Leu176 .

IL-20 plays a critical role in regulating the proliferation and differentiation of keratinocytes during inflammation, particularly in skin-related conditions . It is also involved in the expansion of multipotential hematopoietic progenitor cells . IL-20 is known to be a key player in the induction and maintenance of psoriasis .

IL-20 requires an IL-β-subunit receptor (IL-20RB) for signaling, which can form a functional heterodimeric receptor with either the α-subunit of the IL-20 receptor (IL-20RA) or the α1-subunit of the IL-22 receptor (IL-22RA1) . These receptor variants allow efficient IL-20 signaling . Receptors for IL-20 are expressed in various tissues, including the skin, lungs, ovary, testes, and placenta .

Anti-IL-20 monoclonal antibodies have been researched as potential treatments for conditions such as psoriasis, rheumatoid arthritis, atherosclerosis, osteoporosis, and stroke . These antibodies have shown promise in reducing the severity of rheumatoid arthritis in animal models and mitigating bone destruction .

Recombinant Mouse IL-20 is stable for six to twelve months when stored desiccated at -20°C to -70°C . After reconstitution, it can be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer . It is important to avoid repeated freeze-thaw cycles to maintain the protein’s integrity .