IFNAR1 Mouse
Description
IFNAR1 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 411 amino acids (27-429a.a) and having a molecular mass of 46.8kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).
IFNAR1 is fused to an 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Product Specs
ENLKPPENID VYIIDDNYTL KWSSHGESMG SVTFSAEYRT KDEAKWLKVP ECQHTTTTKC EFSLLDTNVY IKTQFRVRAE EGNSTSSWNE VDPFIPFYTA HMSPPEVRLE AEDKAILVHI SPPGQDGNMW ALEKPSFSYT IRIWQKSSSD KKTINSTYYV EKIPELLPET TYCLEVKAIH PSLKKHSNYS TVQCISTTVA NKMPVPGNLQ VDAQGKSYVL KWDYIASADV LFRAQWLPGY SKSSSGSRSD KWKPIPTCAN VQTTHCVFSQ DTVYTGTFFL HVQASEGNHT SFWSEEKFID SQKHILPPPP VITVTAMSDT LLVYVNCQDS TCDGLNYEII FWENTSNTKI SMEKDGPEFT LKNLQPLTVY CVQARVLFRA LLNKTSNFSE KLCEKTRPGS FSTLEHHHHH H
Product Science Overview
Interferon alpha and beta receptors (IFNAR) are critical components of the immune response in mammals. These receptors are part of the type I interferon receptor family and play a pivotal role in mediating the effects of interferons, which are cytokines involved in antiviral defense, immune regulation, and cell proliferation.
The interferon alpha and beta receptor is a heterodimeric complex composed of two subunits: IFNAR1 and IFNAR2. These subunits belong to the class II cytokine receptor family. The receptor complex mediates the signaling of type I interferons, including interferon-alpha (IFN-α) and interferon-beta (IFN-β), by binding to these cytokines and initiating a cascade of intracellular events that lead to the expression of interferon-stimulated genes (ISGs).
- IFNAR1: This subunit is approximately 100-130 kDa in size and is responsible for binding to the interferon molecules. It is essential for the receptor’s ability to mediate the biological effects of interferons .
- IFNAR2: This subunit exists in multiple isoforms, including a long form that participates in signal transduction and a short form that acts as a decoy receptor. The long form of IFNAR2 is crucial for the activation of downstream signaling pathways .
Recombinant mouse IFNAR proteins are produced using advanced biotechnological methods. These recombinant proteins are used in research to study the signaling mechanisms and biological effects of interferons in a controlled environment. The recombinant mouse IFNAR1 protein, for example, is derived from a mouse myeloma cell line and is purified to high standards to ensure its functionality in experimental settings .
The interferon alpha and beta receptor is integral to the immune response against viral infections. Upon binding to their respective receptors, IFN-α and IFN-β trigger the activation of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway. This leads to the transcription of ISGs, which encode proteins that inhibit viral replication, enhance antigen presentation, and modulate the activity of immune cells .
In addition to their antiviral properties, type I interferons and their receptors are involved in the regulation of cell growth and differentiation. They have been shown to suppress the proliferation of cancer cells and modulate the immune response in various autoimmune diseases .
Recombinant mouse IFNAR proteins are valuable tools in biomedical research. They are used to investigate the molecular mechanisms of interferon signaling, study the effects of interferons on different cell types, and develop therapeutic strategies for diseases such as multiple sclerosis, hepatitis, and certain cancers .
In clinical settings, recombinant interferons are used as therapeutic agents to treat viral infections and immune-related disorders. Understanding the interactions between interferons and their receptors is crucial for optimizing these treatments and developing new therapeutic approaches .
