IFNAR1 Human
Sf9, Insect cells.
IFN-alpha/beta R1, IFNAR1, AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC, Interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1.
Sterile filtered colorless solution.
Greater than 95.0% as determined by SDS-PAGE.
Description
IFNAR1 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 415 amino acids (28-436a.a.) and having a molecular mass of 47.9kDa. IFNAR1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
IFN-alpha/beta R1, IFNAR1, AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC, Interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1.
Sf9, Insect cells.
KNLKSPQKVE VDIIDDNFIL RWNRSDESVG NVTFSFDYQK TGMDNWIKLS GCQNITSTKC NFSSLKLNVY EEIKLRIRAE KENTSSWYEV DSFTPFRKAQ IGPPEVHLEA EDKAIVIHIS PGTKDSVMWA LDGLSFTYSL VIWKNSSGVE ERIENIYSRH KIYKLSPETT YCLKVKAALL TSWKIGVYSP VHCIKTTVEN ELPPPENIEV SVQNQNYVLK WDYTYANMTF QVQWLHAFLK RNPGNHLYKW KQIPDCENVK TTQCVFPQNV FQKGIYLLRV QASDGNNTSF WSEEIKFDTE IQAFLLPPVF NIRSLSDSFH IYIGAPKQSG NTPVIQDYPL IYEIIFWENT SNAERKIIEK KTDVTVPNLK PLTVYCVKAR AHTMDEKLNK SSVFSDAVCE KTKPGNTSKH HHHHH.
Product Science Overview
Interferon Alpha and Beta Receptor Subunit 1 (IFNAR1) is a crucial component of the type I interferon receptor complex. This receptor plays a significant role in the immune response, particularly in antiviral defense mechanisms. The recombinant form of IFNAR1 is used in various research and therapeutic applications.
IFNAR1 is a type I membrane protein that forms one of the two chains of the receptor for type I interferons, including interferon-alpha, -beta, and -lambda . The receptor complex is composed of two subunits: IFNAR1 and IFNAR2. IFNAR1 is the low-affinity subunit, while IFNAR2 is the high-affinity subunit .
Upon binding of type I interferons, the receptor activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway . This activation leads to the phosphorylation of several proteins, including STAT1 and STAT2, which then translocate to the nucleus to modulate the expression of interferon-stimulated genes (ISGs) . These genes encode proteins that have antiviral, antiproliferative, and immunomodulatory functions.
The type I interferon receptor, including IFNAR1, is essential for the body’s defense against viral infections. It mediates the effects of interferons, which are cytokines that have potent antiviral activities. The activation of the interferon receptor leads to a cascade of signaling events that result in the expression of ISGs, which inhibit viral replication and modulate the immune response .
Mutations or deficiencies in IFNAR1 can lead to severe immunodeficiency disorders, making individuals more susceptible to viral infections . Additionally, the recombinant form of IFNAR1 is used in research to study the mechanisms of interferon signaling and to develop therapeutic strategies for viral infections and other diseases.
