AZGP1 Human
Alpha-2-Glycoprotein 1 Zinc-Binding Human
Cat. No.
BT27395
Source
Human Serum.
Synonyms
Zn-alpha-2-glycoprotein, Zn-alpha-2-GP, AZGP1, ZAG, Zinc-alpha-2-glycoprotein, ZNGP1, ZA2G.
Appearance
Filtered White lyophilized (freeze-dried) powder.
Purity
Greater than 80% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
The Human Zinc-Alpha 2 Glycoprotein produced from Human Serum has a molecular mass of 32.14kDa (calculated without glycosylation) containing 278 amino acid residues.
Product Specs
Introduction
Zinc-alpha-2-glycoprotein (ZAG), also known as tumor-derived lipid mobilizing factor (LMF), is a protein present in various body fluids. It plays a role in lipolysis, body weight regulation, melanin production, and potentially in reducing adiposity. ZAG exhibits a class I major histocompatibility complex (MHC) fold but exists as a soluble protein. It possesses an open apical groove, suggesting the binding of a yet-to-be-identified ligand crucial for its biological activity. Understanding ZAG's interactions with compounds is vital for unraveling its signaling function and potential therapeutic applications.
Description
Human Zinc-Alpha 2 Glycoprotein, derived from Human Serum, has a molecular weight of 32.14 kDa (excluding glycosylation) and comprises 278 amino acids.
Physical Appearance
White, lyophilized powder after filtration.
Formulation
ZA2G protein, after filtration at 0.4 µm, is lyophilized to a concentration of 0.5 mg/ml in a buffer of 20mM TRIS and 50mM NaCl, at pH 8.0.
Solubility
To prepare a working stock solution of about 0.5 mg/ml, add deionized water to the lyophilized pellet and allow it to dissolve completely. This product is not sterile; for cell culture applications, filter it through a sterile filter.
Stability
Store the lyophilized protein at -20°C. After reconstitution, aliquot the product to minimize freeze-thaw cycles. The reconstituted protein remains stable at 4°C for up to two weeks.
Purity
The purity is determined to be greater than 80% using SDS-PAGE analysis.
Human Virus Test
Donor blood samples have been tested and confirmed negative for HBsAg, anti-HCV, HIV Ag/Ab, and syphilis.
Synonyms
Zn-alpha-2-glycoprotein, Zn-alpha-2-GP, AZGP1, ZAG, Zinc-alpha-2-glycoprotein, ZNGP1, ZA2G.
Source
Human Serum.
Amino Acid Sequence
QENQDGRYSL TYIYTGLSKH VEDVPAFQAL GSLNDLQFFR YNSKDRKSQP MGLWRQVEGM EDWKQDSQLQ KAREDIFMET LKDIVEYYND SNGSHVLQGR FGCEIENNRS SGAFWKYYYD GKDYIEFNKE IPAWVPFDPA AQITKQKWEA EPVYVQRAKA YLEEECPATL RKYLKYSKNI LDRQDPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT RAGEVQEPEL RGDVLHNGNG TYQSWVVVAV PPQDTAPYSC HVQHSSLAQP LVVPWEAS.
Product Science Overview
Gene Location and Expression
Biological Functions
AZGP1 plays several important roles in the body:
- Stimulates Lipolysis: It stimulates lipid degradation in adipocytes, leading to extensive fat loss associated with some advanced cancers .
- Immune Response: It is involved in the immune response and has been identified as a biomarker in cancer patients .
- Cell Adhesion and Sensory Perception: It is involved in cell adhesion and the detection of chemical stimuli involved in the sensory perception of bitter taste .
Clinical Significance
AZGP1 has been associated with various diseases and conditions:
- Cancer: It is known to be a biomarker in cancer patients, with its role varying depending on the specific type of cancer .
- Diabetes: Decreased circulating levels of AZGP1 are associated with Type 2 diabetes .
- Weight Regulation: Smoking increases the expression of this gene, which is why smoking cessation often leads to weight gain .
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