HTLV 1 TAX antibody

Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that is the etiological agent for Adult T-Cell Leukemia/Lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). One of the key proteins encoded by HTLV-1 is the Tax protein, which plays a crucial role in the virus’s ability to transform and immortalize infected cells .

The HTLV-1 Tax protein is a 40 kDa cell-transforming oncoprotein. It functions as a transcriptional activator and has the ability to modulate the expression and function of many cellular genes. Tax is known to interact with several cellular signal-transduction pathways, including the CREB/ATF and NFkB pathways, and deregulates the expression of downstream genes that mediate cell cycle control .

Tax has been shown to be oncogenic because it transforms and immortalizes rodent fibroblasts and human T-lymphocytes. It stimulates cell growth by direct binding to cyclin-dependent kinase holenzymes and/or inactivating tumor suppressors such as p53 and DLG .

The HTLV-1 Tax (Mouse Antibody) is a monoclonal antibody that specifically targets the HTLV-1 Tax protein. It is commonly used in various research applications, including Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), and Enzyme-Linked Immunosorbent Assay (ELISA) .

Applications

1. Western Blot (WB): Used to detect the presence of HTLV-1 Tax protein in cell lysates.
2. Immunofluorescence (IF): Allows visualization of HTLV-1 Tax protein within cells.
3. Immunohistochemistry (IHC): Used to detect HTLV-1 Tax protein in tissue samples.
4. ELISA: Used to quantify the amount of HTLV-1 Tax protein in various samples .

The HTLV-1 Tax (Mouse Antibody) is a valuable tool for researchers studying the mechanisms of HTLV-1-mediated transformation and the role of Tax in oncogenesis. By understanding how Tax interacts with cellular pathways and modulates gene expression, scientists can develop targeted therapies for HTLV-1-associated diseases .