HOMER1 Antibody

Homer Homolog-1, Mouse Anti Human
Cat. No.
BT20226
Source
Synonyms
HOMER, SYN47, Ves-1, HOMER1A, HOMER1B, HOMER1C, HOMER1, Homer protein homolog 1.
Appearance
Purity
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs
In Stock
Quick Inquiry

Description

Product Specs

Introduction
HOMER1, a member of the Homer family of proteins, plays a crucial role in regulating signal transduction, trafficking of glutamate receptors, and maintaining extracellular glutamate levels in corticolimbic brain regions. It is primarily located at excitatory synapses and exhibits binding affinity for group 1 metabotropic glutamate receptors (mGluRs), influencing the susceptibility to TRAIL-mediated apoptosis.
Formulation
The antibody is supplied in a solution containing 1mg/ml in PBS buffer at pH 7.4 with 0.1% sodium azide.
Storage Procedures
For short-term storage (up to 1 month), maintain the antibody at 4°C. For extended periods, store at -20°C. Avoid repeated freeze-thaw cycles to ensure stability.
Stability / Shelf Life
The antibody remains stable for 12 months when stored at -20°C and for 1 month at 4°C.
Applications
This HOMER1 antibody has undergone rigorous testing using ELISA and Western blot analysis, confirming its specificity and reactivity. While the recommended dilution range for Western blot analysis is 1:1000 to 1:2000, with a starting dilution of 1:1000, it is advised to optimize the dilution for each specific application to achieve optimal results.
Synonyms
HOMER, SYN47, Ves-1, HOMER1A, HOMER1B, HOMER1C, HOMER1, Homer protein homolog 1.
Purification Method
HOMER1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Type
Mouse Anti Human Monoclonal.
Clone
PAT1F3AT.
Immunogen
Anti-human HOMER1 mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HOMER1 amino acids 1-354 purified from E. coli.
Ig Subclass
Mouse IgG2b heavy chain and κ light chain.

Product Science Overview

Introduction

Homer protein homolog 1 (HOMER1) is a neuronal protein encoded by the HOMER1 gene in humans. It is also known by other names such as Vesl and PSD-Zip45 . HOMER1 plays a crucial role in the central nervous system, particularly in the regulation of synaptic transmission and plasticity.

Structure and Function

HOMER1 is an approximately 48 kDa cytoplasmic protein that regulates the cell surface localization of neuronal metabotropic glutamate receptors (mGluR1 and mGluR5) . These receptors are involved in various neural processes, including learning, memory, and synaptic plasticity. HOMER1 interacts with these receptors to modulate their signaling pathways and ensure proper synaptic function.

Antibody Specificity

The mouse anti-human HOMER1 antibody is a monoclonal antibody that specifically detects human HOMER1 in various applications, including Western blot and ELISA . The antibody is produced by immunizing mice with a synthetic peptide corresponding to a specific region of the human HOMER1 protein . This ensures high specificity and affinity for the target protein.

Applications

The mouse anti-human HOMER1 antibody is widely used in research to study the expression and function of HOMER1 in different tissues and cell types. It is particularly useful in neuroscience research to investigate the role of HOMER1 in synaptic transmission and plasticity. The antibody can be used in various experimental techniques, including:

  • Western Blotting: To detect HOMER1 protein levels in tissue and cell lysates.
  • Immunohistochemistry: To visualize the localization of HOMER1 in tissue sections.
  • ELISA: To quantify HOMER1 protein levels in biological samples.

Quick Inquiry

Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *

Category

Service

Related Products

HOMER1 Human
Homer Homolog-1 Human Recombinant
Cat. No.
BT22314
Source
Escherichia Coli.
THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
  • Contact
  • Address: 1925 E Maple Ave, El Segundo, CA 90245 United States
  • Phone : +1 201-285-7826
  • Email : info@thebiotek.com
  • Hours : Mon.-Fri. 9:00 AM - 5:00 PM
© Copyright 2024 Thebiotek. All Rights Reserved.