HLA-G Human
Major Histocompatibility Complex, Class I, G, HLA-G Histocompatibility Antigen, Class I, G, MHC Class I Antigen G, B2 Microglobulin, HLA G Antigen, HLA Class I Histocompatibility Antigen, Alpha Chain G, Mutant MHC Class Ib Antigen, Mutant MHC Class I Antigen, MHC Class Ib Antigen, HLA-6.0, MHC-G, HLAG, HLA class I histocompatibility antigen, alpha chain G, HLA G antigen, MHC class I antigen G.
Description
HLA-G Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 309 amino acids (25-308 a.a) and having a molecular mass of 35.3kDa.
HLA-G is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Major Histocompatibility Complex, Class I, G, HLA-G Histocompatibility Antigen, Class I, G, MHC Class I Antigen G, B2 Microglobulin, HLA G Antigen, HLA Class I Histocompatibility Antigen, Alpha Chain G, Mutant MHC Class Ib Antigen, Mutant MHC Class I Antigen, MHC Class Ib Antigen, HLA-6.0, MHC-G, HLAG, HLA class I histocompatibility antigen, alpha chain G, HLA G antigen, MHC class I antigen G.
MGSSHHHHHH SSGLVPRGSH MGSHMGSHSM RYFSAAVSRP GRGEPRFIAM GYVDDTQFVR FDSDSACPRM EPRAPWVEQE GPEYWEEETR NTKAHAQTDR MNLQTLRGYY NQSEASSHTL QWMIGCDLGS DGRLLRGYEQ YAYDGKDYLA LNEDLRSWTA ADTAAQISKR KCEAANVAEQ RRAYLEGTCV EWLHRYLENG KEMLQRADPP KTHVTHHPVF DYEATLRCWA LGFYPAEIIL TWQRDGEDQT QDVELVETRP AGDGTFQKWA AVVVPSGEEQ RYTCHVQHEG LPEPLMLRWK QSSLPTIPI.
Product Science Overview
The Major Histocompatibility Complex (MHC) is a set of genes that play a crucial role in the immune system by helping the body recognize foreign substances. Among the various classes of MHC molecules, Class I molecules are particularly important for presenting endogenous antigens to CD8+ T cells. One specific type of MHC Class I molecule is HLA-G, which has unique properties and functions.
HLA-G (Human Leukocyte Antigen-G) is a non-classical MHC Class I molecule. Unlike classical MHC Class I molecules (HLA-A, HLA-B, and HLA-C), HLA-G has limited polymorphism and is primarily involved in immune tolerance rather than antigen presentation . The HLA-G molecule consists of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the cell membrane and is approximately 45 kDa in size .
HLA-G is expressed on fetal-derived placental cells and plays a critical role in maternal-fetal tolerance during pregnancy . It helps prevent the maternal immune system from attacking the fetus, which is genetically different from the mother. HLA-G achieves this by interacting with inhibitory receptors on immune cells, thereby suppressing their activity .
Recombinant HLA-G refers to the HLA-G protein produced through recombinant DNA technology. This involves inserting the HLA-G gene into a suitable expression system, such as bacteria or mammalian cells, to produce the protein in large quantities. Recombinant HLA-G is used in various research applications to study its role in immune regulation and potential therapeutic uses.
HLA-G has been associated with several clinical conditions. For instance, its expression is linked to successful pregnancy outcomes, and abnormalities in HLA-G expression have been observed in cases of pre-eclampsia . Additionally, HLA-G is being investigated for its potential role in transplant tolerance and autoimmune diseases .
