HK2 Antibody

Hexokinase-2 (HK2) is an enzyme that plays a crucial role in glucose metabolism. It is encoded by the HK2 gene located on chromosome 2 in humans . This enzyme is predominantly found in skeletal muscle and is known for its role in phosphorylating glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways .

Hexokinase-2 localizes to the outer membrane of mitochondria and is insulin-responsive . It is involved in the increased rate of glycolysis observed in rapidly growing cancer cells . The enzyme’s activity is essential for maintaining cellular glucose homeostasis and regulating glucose import .

Hexokinase-2 has been found to be highly expressed in various malignant cancers, including gliomas . Its expression is significantly higher in lower-grade glioma and glioblastoma compared to adjacent normal tissue . The enzyme’s activity is associated with poor prognosis in glioma patients, as it is involved in multiple immune-related signaling pathways that regulate immune responses and the infiltration of immune cells .

The mouse anti-human hexokinase-2 antibody is a monoclonal antibody that specifically recognizes human hexokinase-2. This antibody is used in various research applications, including western blotting, immunocytochemistry, and flow cytometry . It is produced by immunizing mice with full-length recombinant human hexokinase-2 protein .

The mouse anti-human hexokinase-2 antibody is widely used in cancer research to study the enzyme’s role in tumor growth and metabolism . It helps in detecting hexokinase-2 expression in different cell lines and tissues, providing valuable insights into the enzyme’s function and regulation .