HIV 1 gp41 Antibody

The human immunodeficiency virus (HIV) is a type of virus known as a retrovirus. It weakens the immune system, making individuals susceptible to infections that wouldn't typically pose a threat. HIV primarily targets specific cells crucial for a healthy immune response, such as helper T cells (particularly CD4+ T cells), macrophages, and dendritic cells. The virus diminishes the number of CD4+ T cells through three primary mechanisms: direct destruction of infected cells, increased programmed cell death (apoptosis) in infected cells, and elimination of infected CD4+ T cells by CD8 cytotoxic lymphocytes that identify and target infected cells. When the CD4+ T cell count drops significantly, the body's ability to fight off infections is compromised, leading to a heightened risk of opportunistic infections. HIV belongs to the Lentivirus genus, which is part of the Retroviridae family. Lentiviruses share common characteristics in terms of their structure and behavior. They are known to infect a wide range of species, often causing prolonged illnesses with extended periods before symptoms appear. These viruses are transmitted as single-stranded, positive-sense RNA viruses enclosed within an envelope. Upon entering a host cell, the virus's RNA genome is converted into double-stranded DNA by an enzyme called reverse transcriptase, which is carried within the virus particle. This newly formed viral DNA is then incorporated into the host cell's DNA using another virally encoded enzyme called integrase. This integration allows the virus's genetic material to be transcribed. Once the virus has infected a cell, two scenarios are possible: the virus can either enter a dormant state (latency), allowing the infected cell to continue functioning normally, or it can become active and replicate, producing numerous new virus particles that can infect other cells.

This product is a rabbit serum solution containing antibodies that specifically target the HIV-1 protein, DEV-I. This protein is a recombinant form of the virus's envelope protein and comprises the C-terminal portion of gp120 and a significant part of gp41. It is produced in E. coli.

A clear, sterile solution that has been passed through a filter.

This product should be stored at a temperature of -20 degrees Celsius below zero.

The product can be stored for a period of one year when frozen. Once thawed, it remains stable for one month if kept at a temperature of 4 degrees Celsius.

Immunoreactive with HIV-I gp41. Generates a Strong positive control spot on Immuno-blot tests. Generates 1 OD (410nm) at a dilution of 1: 250 on AS 1001 (DEV-1) ELISA.

Polyclonal Rabbit Antibody.