HEV ORF2 (633-659 a.a.)

Hepatitis E virus (HEV) is a positive-sense, single-stranded RNA virus that belongs to the Hepeviridae family . It is a zoonotic pathogen responsible for causing hepatitis in both humans and animals, leading to acute hepatitis E outbreaks worldwide . The HEV genome is approximately 7.2 kb in length and encodes three well-defined open reading frames (ORFs): ORF1, ORF2, and ORF3 .

The ORF2 protein is the major structural protein of HEV and forms the viral capsid . It plays a crucial role in the virus’s life cycle, including viral replication, pathogenesis, and immune response regulation . The ORF2 protein is also involved in the development of vaccines and diagnostic tools for HEV .

The recombinant ORF2 (633-659 a.a.) is a specific fragment of the ORF2 protein. This fragment has been studied for its potential applications in immunization protocols and antibody generation . The recombinant protein is produced using advanced biotechnological methods to ensure high sensitivity, specificity, and reproducibility .

The ORF2 protein, including the 633-659 a.a. fragment, has multiple functions beyond forming the viral capsid. It is involved in:

• Viral Replication: The ORF2 protein plays a role in the replication of HEV by interacting with host cellular machinery .
• Immune Response Regulation: The protein modulates the host’s innate immune response and cellular signaling pathways .
• Pathogenesis: ORF2 is implicated in the pathogenesis of HEV, contributing to the virus’s ability to cause disease .

The recombinant ORF2 (633-659 a.a.) fragment is valuable in various research and medical applications:

• Vaccine Development: The ORF2 protein is a target for vaccine development due to its immunogenic properties .
• Diagnostic Tools: Recombinant ORF2 fragments are used in diagnostic assays to detect HEV infections .
• Antibody Generation: The recombinant protein is used to generate specific antibodies for research and therapeutic purposes .