HDHD2 Human
Description
HDHD2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
For short-term storage (2-4 weeks), the product can be stored at 4°C. For longer storage, freezing at -20°C is recommended.
To further enhance long-term stability, consider adding a carrier protein (0.1% HSA or BSA) to the solution.
Repeated freezing and thawing of the product should be avoided.
Product Science Overview
The HDHD2 gene is located on chromosome 18 and encodes a protein that consists of 259 amino acids . The protein has a molecular weight of approximately 29 kDa. The HDHD2 protein contains several key features, including binding sites for magnesium ions, which are essential for its enzymatic activity .
HDHD2 is predicted to be involved in dephosphorylation processes, which means it plays a role in removing phosphate groups from molecules . This activity is crucial for various cellular processes, including signal transduction and metabolism. The enzyme binds to magnesium ions, which act as cofactors and are necessary for its catalytic function .
HDHD2 is primarily located in the extracellular exosome, which is a type of vesicle involved in cell communication and the transport of molecules between cells . The protein’s role in dephosphorylation suggests it may be involved in regulating various cellular pathways and maintaining cellular homeostasis.
Mutations or alterations in the HDHD2 gene have been associated with certain genetic disorders, such as Chromosome 18p Deletion Syndrome . This syndrome is characterized by a range of developmental and physical abnormalities. Understanding the function and regulation of HDHD2 can provide insights into the molecular mechanisms underlying these conditions and potentially lead to therapeutic interventions.
Recombinant HDHD2 protein is used in various research applications to study its enzymatic properties and biological functions. By expressing and purifying the human recombinant form of HDHD2, researchers can investigate its structure, function, and interactions with other molecules. This knowledge can contribute to the development of targeted therapies for diseases associated with HDHD2 dysfunction.
